Publications
Our former award recipients often notify us of the publication of journal articles and other materials that summarize research that was supported in part by a Foundation grant.
- FY2022 Grant Recipients
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Title of the research project Y Chromosomal Genes Protective against Heart Failure Recipient (Institution) Soichi Sano (Osaka Metropolitan University , Department of Cardiology, Graduate School of Medicine) Journal article / other material Nature Cardiovascular Research
doi.org/10.1038/s44161-024-00441-zTitle of the paper Disruption of the Uty epigenetic regulator locus in hematopoietic cells phenocopies the profibrotic attributes of Y chromosome loss in heart failure Title of the research project Elucidation of Novel Regulatory Mechanism of Glucose Metabolism in Liver Type 2 Innate Lymphocytes by Single Cell Analysis and Spatial Transcriptome Analysis Recipient (Institution) Tomoaki Tanaka (Chiba University, Department of Molecular Diagnosis, Professor) Journal article / other material Nat Commun . 2022 Sep 15;13(1):5408. doi: 10.1038/s41467-022-33171-6 Title of the paper Liver group 2 innate lymphoid cells regulate blood glucose levels through IL-13 signaling and suppression of gluconeogenesis Journal article / other material Commun Biol. 2023; 6: 787. doi: 10.1038/s42003-023-05160-y Title of the paper Identification of genotype–biochemical phenotype correlations associated with fructose 1,6-bisphosphatase deficiency Title of the research project Elucidation of the role of alveolar capillary in alveolar formation for clinical application Recipient (Institution) Haruko Takano (Nippon Medical School, Department of Molecular Pathophysiology, Institute of Advanced Medical Science) Journal article / other material Nature communications doi.org/10.1038/s41467-024-45910-y Title of the paper Endothelial cells regulate alveolar morphogenesis by constructing basement membranes acting as a scaffold for myofibroblasts Title of the research project Development of three component reaction for site-selective peptide modification Recipient (Institution) Kazuya Kanemoto (Tohoku University, Graduate School of Pharmaceutical Sciences) Journal article / other material Angew. Chem. Int. Ed. 2024, doi.org/10.1002/anie.202320012 Title of the paper N-Terminal-Specific Dual Modification of Peptides through Copper-Catalyzed [3+2] Cycloaddition Journal article / other material J. Am. Chem. Soc. 2024, 146, 3910.3919 doi.org/10.1021/jacs.3c11524 Title of the paper Carboiodanation of Arynes: Organoiodine(III) Compounds as Nucleophilic Organometalloids Journal article / other material Org. Lett. 2024, 26, 438.443 doi.org/10.1021/acs.orglett.3c03419 Title of the paper Amination of N.(Organodithio)phthalimides for the Modular Synthesis of Aminodisulfides Journal article / other material Chem. Eur. J. 2024, e202400894 doi.org/10.1002/chem.202400894 Title of the paper Amino- and Alkoxybenziodoxoles: Facile Preparation and Use as Arynophiles Journal article / other material Orcid.org/0000-0002-3958-7369 doi.org/10.26434/chemrxiv-2024-1vp1n Title of the paper Disulfuration of Azlactones: A Versatile Entry to Unnatural,Disulfide-Linked Amino Acids and Peptides Journal article / other material Org. Lett. 2024, 26, 1880.1885 doi.org/10.1021/acs.orglett.4c00184 Title of the paper Construction of Diverse Pyrrolidine-Based Skeletons through the Ag-Catalyzed Stereoselective Addition.Elimination Reaction of Azomethine Ylides with Nitroallyl Acetates Journal article / other material orcid.org/0000-0002-3958-7369 doi.org/10.26434/chemrxiv-2024-1917n Title of the paper Precision Synthesis of Chimeric Peptides through Site-Specific Azomethine Ylide.Dehydroalanine Cycloaddition Title of the research project Molecular basis of calcium ion-regulated cellular uptake of nutrients into cancer cells Recipient (Institution) Hisaaki Hirose (Kyoto University, Institute for Chemical Research) Journal article / other material Genes Cells. 2024 doi: 10.1111/gtc.13118 Title of the paper ATP2B4 is an essential gene for epidermal growth factor-induced macropinocytosis in A431 cells Title of the research project Defective mitophagy in pancreatic beta-cells leads to diabetes Recipient (Institution) Kyota Aoyagi (Kyorin University School of Medicine, Department of Cellular Biochemistry) Journal article / other material nature.com/scientificreports/ doi.org/10.1038/s41598-024-56769-w Title of the paper Imeglimin mitigates mitochondria to restore insulin secretion and suppress apoptosis of pancreatic β.cells from db/db mice Title of the research project Interorgan networks of islets with liver, fat, or macrophages to regulate β-cell mass Recipient (Institution) Jun Shirakawa (Gunma University, Institute for Molecular and Cellular Regulation (IMCR) ) Journal article / other material Endocrinology, 2023, 164, 1.13 doi.org/10.1210/endocr/bqad095 Title of the paper Protective Effects of Imeglimin and Metformin Combination Therapy on β-Cells in db/db Male Mice Title of the research project The mechanism of early placental development regulated by a virus-derived gene Recipient (Institution) Hirosuke Shiura (University of Yamanashi, Graduate Faculty of Interdisciplinary Research) Journal article / other material Frontiers in Cell and Developmental Biology 01 frontiersin.org doi 10.3389/fcell.2023.1273638 Title of the paper Roles of retrovirus-derived PEG10 and PEG11/RTL1 in mammalian development and evolution and their involvement in human disease Title of the research project Elucidation of the disease development caused by disruption of a novel phospholipid transport factor required for mitochondrial homeostasis Recipient (Institution) Yasuhiro Horibata (Dokkyo Medical University School of Medicine, Department of Biochemistry) Journal article / other material Archives of Biochemistry and Biophysics 752 (2024) 109871 doi.org/10.1016/j.abb.2023.109871 Title of the paper The ceramide transport protein CERT is involved in alkylacylglycerol transfer from the ER to the Golgi for the biosynthesis of ether phospholipid Title of the research project Development and application of stereoselective synthesis of cyclopropane-fused heteropolycyclic compounds Recipient (Institution) Tetsuya Tsujihara (Iwate Medical University, Department of Medicinal and Organic Chemistry, School of Pharmacy) Journal article / other material Org. Lett. 2024, 26, 6502–6506. doi.org/10.1021/acs.orglett.4c02416 Title of the paper Enantioselective One-Pot Synthesis of Cyclopropane-Fused Tetrahydroquinolines via a Ru-Catalyzed Intramolecular Cyclopropanation
- FY2021 Grant Recipients
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Title of the research project Molecular mechanism of lysosomal damage repair by TFEB Recipient (Institution) Shuhei Nakamura（Graduate School of Frontier Biosciences, Osaka University） Journal article / other material PLOS Genetics doi.org/10.1371/journal.pgen.1010264 Title of the paper PACSIN1 is indispensable for amphisomelysosome fusion during basal autophagy and subsets of selective autophagy Journal article / other material Proceedings of the National Academy of Sciences of the United States of America 121(2) e2306454120 2024 doi.org/10.1073/pnas.2306454120 Title of the paper HKDC1, a target of TFEB, is essential to maintain both mitochondrial and lysosomal homeostasis, preventing cellular senescence Journal article / other material EMBO Rep. 2023 Dec 6;24(12):e57300. doi:10.15252/embr.202357300 Title of the paper Microautophagy regulated by STK38 and GABARAPs is essential to repair lysosomes and prevent aging. Journal article / other material Proc Natl Acad Sci U S A . 2023 Sep 26;120(39):e2221553120. doi: 10.1073/pnas.2221553120. Epub 2023 Sep 18. Title of the paper Neuronal MML-1/MXL-2 regulates systemic aging via glutamate transporter and cell nonautonomous autophagic and peroxidase activity. Title of the research project Investigation of cellular dynamics of CD73-expressing mesenchymal stem cells in the bone marrow microenvironment Recipient (Institution) Kenichi Kimura (Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance, University of Tsukuba) Journal article / other material biorxiv, May 7th 2024, doi.org/10.1101/2024.05.02.592287 Title of the paper A novel genetic mouse model of fatal aortic dissection reveals massive inflammatory cell infiltration in the thoracic aorta Title of the research project Structural and functional analysis of primary cation transporters and elucidation of the substrate specificity by gain-of-function mutant Recipient (Institution) Kazuhiro Abe（Graduate school of Pharmaceutical Sciences, Nagoya University, Associate Proffessor） Journal article / other material Nature communications 09 Sept. 2022
doi.org/10.1038/s41467-022-32793-0Title of the paper Structure and function of H+/K+ pump mutants reveal Na+/K+ pump mechanisms Journal article / other material Communications Biology, 2023, 6, 956, doi.org/10.1038/s42003-023-05334-8 Title of the paper Deep learning driven de novo drug design based on gastric proton pump structures Journal article / other material Biochim Biophys Acta Mol Cell Res, 2023, 1870, 119543, doi.org/10.1016/j.bbamcr.2023.119543 Title of the paper An unusual conformation from Na+-sensitive non-gastric proton pump mutants reveals molecular mechanisms of cooperative Na+-binding Title of the research project Hematopoietic stem cell aging and mitochondria aging Recipient (Institution) Takayoshi Matsumura（Division of Inflammation Research, Center for Molecular Medicine. Division of Cardiovascular Medicine., Jichi Medical University） Journal article / other material Nature Communications | ( 2022) 13:7064
doi.org/10.1038/s41467-022-34906-1Title of the paper A Myb enhancer-guided analysis of basophil and mast cell differentiation Title of the research project Significance and spatial profiling of phospholipid metabolism in NASH Recipient (Institution) Hayato Nakagawa（Department of Gastroenterology and Hepatology, Mie University） Journal article / other material J Clin Invest. 2022;132(11):e151895. doi.org/10.1172/JCI151895. Title of the paper Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatohepatitis Title of the research project Cryo-electron microscopy studies for disease pathogenesis of Xeroderma Pigmentosum Recipient (Institution) Syota Matsumoto（Institute for Quantitative Biosciences, The university of Tokyo） Journal article / other material Cancer Science.23-May-2023, doi.org/10.1111/cas.15850 Title of the paper Chromatin structure related to oncogenesis Title of the research project Analysis of brain aging caused by the disruption of "nuclear-axon crosstalk" machinery Recipient (Institution) Kenichiro Kuwako（School of Medicine, Department of Neural and Muscular Physiology , Shimane University, Associate Professor） Journal article / other material Development (2022) 149, dev201214.
doi:10.1242/dev.201214Title of the paper N-WASP-Arp2/3 signaling controls multiple steps of dendrite maturation in Purkinje cells in vivo Title of the research project Development of asymmetric synthesis of sulfoximine analogs as bioisosteres Recipient (Institution) Taichi Kano (Graduate School of Engineering, Tokyo University of Agriculture and Technology) Journal article / other material Organic Letters, 2023, 25, 6677-6681 doi.org/10.1021/acs.orglett.3c02534 Title of the paper Transsulfinamidation of Sulfinamides with Amines Title of the research project Achieve a comprehensive understanding of the pathogenesis of type 1 diabetes mellitus, leading to development of the prevention measures Recipient (Institution) Keiichiro Mine (Division of Metabolism and Endocrinology, Department of Internal Medicine, Faculty of Medicine, Saga University) Journal article / other material Nature Communications | ( 2024) 15:1337 doi.org/10.1038/s41467-024-45573-9 Title of the paper TYK2 signaling promotes the development of autoreactive CD8+ cytotoxic T lymphocytes and type 1 diabetes Title of the research project Potential implications of enzymatic activity of the multifunctional protease NRDC as a new therapeutic target for cardiovascular disease Recipient (Institution) Mikiko Ohno (Department of Pharmacology, Shiga University of Medical Science) Journal article / other material Internal and Emergency Medicine 6 December 2023 doi.org/10.1007/s11739-023-03508-0 Title of the paper Auxiliary roles of nardilysin in the early diagnosis of acute coronary syndrome: a prospective cohort study, the Nardi.ACS study Journal article / other material Biochemical and Biophysical Research Communications 15 April 2024 doi.org/10.1016/j.bbrc.2024.149961 Title of the paper Nardilysin in vascular smooth muscle cells controls blood pressure via the regulation of calcium dynamics Title of the research project Elucidating the mechanism of skin stem cell aging by targeting anti-aging matrix Fibulin-7 Recipient (Institution) Aiko Sada (International Research Center for Medical Sciences (IRCMS), Kumamoto University) Journal article / other material EMBO Rep . 2022 Dec 6;23(12):e55478. doi: 10.15252/embr.202255478. Epub 2022 Oct 24. Title of the paper The extracellular matrix fibulin 7 maintains epidermal stem cell heterogeneity during skin aging Title of the research project Studies of genetic basis of early onset cardiac conduction system disease and disease mechanism-based personalized medicine Recipient (Institution) Kenshi Hayashi（School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University） Journal article / other material Journal of Molecular and Cellular Cardiology doi.org/10.1016/j.yjmcc.2023.03.001 Title of the paper The utility of zebrafish cardiac arrhythmia model to predict the pathogenicity of KCNQ1 variants Title of the research project Analysis of the mechanism underlying extracellular release of tau for treatment of Alzheimer’s disease Recipient (Institution) Shigeki Arawaka (Department of Internal Medicine IV, Division of Neurology, Faculty of Medicine, Osaka Medical and Pharmaceutical University) Journal article / other material Biochemical and Biophysical Research Communications 725 (2024) 150267 doi.org/10.1016/j.bbrc.2024.150267 Title of the paper Biochemical and Biophysical Research Communications Title of the research project Study of functional deficits of microglia and accelerated onset of neurodegenerative disorders Recipient (Institution) Keiro Shirotani（The Laboratory of Genome-based Drug Discovery, Nagasaki University） Journal article / other material J. Biochem 2022;00(00):1-7 doi.org/10.1093/jb/mvac073 Title of the paper The role of TREM2 N-glycans in trafficking to the cell surface and signal transduction of TREM2 Title of the research project Analysis of ncRNA transcription mediated chromatin modulation mechanism Recipient (Institution) Kouji Hirota (Department of Chemistry, Graduate School of Science, Metropolitan University) Journal article / other material PLoS One. 2024;19(1):e0294191. Epub 2024/01/22. doi: 10.1371/journal.pone.0294191. Title of the paper Metabolic stress-induced long ncRNA transcription governs the formation of meiotic DNA breaks in the fission yeast fbp1 gene Journal article / other material Nat Struct Mol Biol. 2023;30(9):1286-94. Epub 2023/08/18. doi: 10.1038/s41594-023-01064-x. PubMed PMID: 37592094; PubMed Central PMCID: PMCPMC10497406. Title of the paper PCNA recruits cohesin loader Scc2 to ensure sister chromatid cohesion. Journal article / other material DNA Repair (Amst). 2023;127:103503. Epub 2023/04/27. doi: 10.1016/j.dnarep.2023.103503. PubMed PMID: 37099849. Title of the paper CTF18-RFC contributes to cellular tolerance against chain-terminating nucleoside analogs (CTNAs) in cooperation with proofreading exonuclease activity of DNA polymerase ε. Title of the research project Intrinsic barrier dysfunction in multiple sclerosis patient Recipient (Institution) Hideaki Nishihara（Department of Neurotherapeutics, Yamaguchi University） Journal article / other material Adv. Healthcare Mater. 2022, 11, 2200804
doi: 10.1002/adhm.202200804Title of the paper The Modular μSiM: A Mass Produced, Rapidly Assembled,and Reconfigurable Platform for the Study of Barrier Tissue Models In Vitro Journal article / other material Journal of Visualized Experiments 2023 Issue 195, doi: 10.3791/65134 Title of the paper Differentiation of Human Induced Pluripotent Stem Cells to Brain Microvascular Endothelial Cell-Like Cells with a Mature Immune Phenotype. Title of the research project Development of an innovative diagnostic and therapeutic method that combines radionuclide therapy and novel boron neutron capture therapy Recipient (Institution) Kazuma Ogawa (Institute for Frontier Science Initiative, Kanazawa University) Journal article / other material J Med Chem. 65(24) 16741-16753 (2022) doi.org/10.1021/acs.jmedchem.2c01586 Title of the paper An RGD peptide conjugated dodecaborate with Ga-DOTA complex: a preliminary study for the development of theranostic agents for boron neutron capture therapy and its companion diagnostics. Title of the research project Molecular mechanism of neuroprotection after ischemic stroke Recipient (Institution) Hiroo Takahashi（Department of Molecular Neurobiology, Kagawa University） Journal article / other material Neuroscience Research 186 (2023) 3.9
doi: 10.1016/j.neures.2022.10.005. Epub 2022Title of the paper Molecular mechanisms underlying activity-dependent ischemic tolerance in the brain Title of the research project Molecular mechanism for the mutual relationship between macrophage chemotaxis and activation Recipient (Institution) Etsuko Toda（Department of Analytic Human Pathology, Nippon Medical School） Journal article / other material Kidney Int.2022 Dec. doi.org/10.1016/j.kint.2022.07.031 Title of the paper nhibition of the chemokine signal regulator FROUNT by disulfiram ameliorates crescentic glomerulonephritis Title of the research project Catalytic Asymmetric Indole Halocyclization for Construction of Bioactive Structures Recipient (Institution) Keisuke Asano（Institute for Catalysis, Hokkaido University） Journal article / other material Chem. Rec. 2022, e202200200 doi.org/10.1002/tcr.202200200
tcr.wiley-vch.deTitle of the paper Organocatalytic Access to Tetrasubstituted Chiral Carbons Integrating Functional Groups Journal article / other material Chemistry — A European Journal, 2024, 30, e202303399.doi: 10.1002/chem.202303399 Title of the paper trans-Cyclooctenes as Scavengers of Bromine Involved in Catalytic Bromination Title of the research project Analysis of structures and functions of plant nuclear actin microfilaments Recipient (Institution) Noriko Inada (Graduate School of Life and Environmental Sciences, Osaka Prefecture University) Journal article / other material Plant&Cell Physiology, 2023, 64(10), 1231-1242, doi:10.1093/pcp/pcad092 Title of the paper Organocatalytic Access to Tetrasubstituted Chiral Carbons Integrating Functional Groups
- FY2020 Grant Recipients
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Title of the research project Targeting Spliceosomal Mutant Leukemias by a Novel ASO Therapy Recipient (Institution) Akihide Yoshimi（Cancer RNA Research Unit, National Cancer Center Research Institute） Journal article / other material Cancer Sci, 2022 Feb;113(2):373-381. doi: 10.1111 Title of the paper Aberrant RNA splicing and therapeutic opportunities in cancers Title of the research project Molecular basis for early dendritic cell lineage specification during pathogen infection Recipient (Institution) Daisuke Kurotaki（International Research Center for Medical Sciences, Kumamoto University） Journal article / other material PNS August 15, 2022
doi.org/10.1073/pnas.2207009119Title of the paper Chromatin structure undergoes global and local reorganization during murine dendritic cell development and activation Title of the research project Elucidation of the mechanisms of new tubulointerstitial nephritis with IgM-positive plasma cells and comprehensive analysis of IgM-type autoantibodies in the serum Recipient (Institution) Naoki Takahashi（Department of Nephrology, University of Fukui） Journal article / other material CEN Case Reports, 2023,12,32-38
doi.org/10.1007/s13730-022-00715-0Title of the paper Fanconi syndrome in an elderly patient with membranous nephropathy during treatment with the immunosuppressant mizoribine Title of the research project Synthesis and development of flavan-derived polyphenol with protective effect against amyloid-beta-induced toxicity Recipient (Institution) Ken Ohmori（Department of Chemistry, School of Science, Tokyo Institute of Technology） Journal article / other material Angewandte Chemie, International Edition, 2022, 61, e202205106.
doi.org/10.1002/anie.202205106Title of the paper Total Synthesis of Parameritannin A2, a Branched Epicatechin Tetramer with Two Double Linkages Journal article / other material Organic and Biomolecular Chemistry, 2022, 20, 7419-7423.
doi.org/10.1039/D2OB01416ETitle of the paper De novo synthesis od dimerization-ready flavan unit via intramolecular Pummerer/Friedel-Crafts cascade Title of the research project Molecular genetic analysis of plant sub-stomatal chamber development Recipient (Institution) Yuki Yoshida（Faculty of Advanced Science and Technology, Kumamoto University） Journal article / other material Microbiol Spectr. 2021 Sep 3;9(1):e0051121.
doi: 10.1128/Spectrum.00511-21.Title of the paper Entamoeba Chitinase is Required for Mature Round Cyst Formation Title of the research project Highly Efficient Synthesis of Rare Macrolides, Directing Drug Discovery Recipient (Institution) Jun Ishihara (School of pharmaceutical sciences, Pharmaceutical organic chemistry department, Nagasaki University) Journal article / other material Molecules 2024, 29(5), 1187 doi.org/10.3390/molecules29051187 Title of the paper Progress in Lewis-Acid-Templated Diels–Alder Reactions Title of the research project Catalytic Enantioselective α-Halogenation of Acylpyrazoles Directed towards Synthesis of Chiral Drugs Recipient (Institution) Kazuaki Ishihara（Graduate School of Engineering, Nagoya University） Journal article / other material Synlett 2022, 33, 585-588, DOI: 10.1055/a-1750-8481; Art ID: st-2021-v0465-l Title of the paper Thorpe-Ingold Effect on High-Performance Chiral -Copper(II) Catalyst Journal article / other material ACS Catal. 2022, 12, 1012-1017 doi.org/10.1021/acscatal.1c05500 Title of the paper A π-Cu(II)-π Complex as an Extremely Active Catalyst for Enantioselective α-Halogenation of N-Acyl-3,5-dimethylpyrazoles Journal article / other material Journal of the American Chemical Society 2023, 145, 27080-27088 doi.org/10.1021/jacs.3c10820 Title of the paper Tande m Isomerization/α,β-Site-Selective and Enantioselective Addition Reactions of N‑(3-Butynoyl)-3,5-dimethylpyrazole Induced by Chiral π−Cu(II) Catalysts Title of the research project Research on infertility Recipient (Institution) Keiichiro Ishiguro（Institute of Molecular Embryology and Genetics, Kumamoto University） Journal article / other material NATURE COMMUNICATIONS 2021
doi.org/10.1038/s41467-021-23378-4Title of the paper Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis Journal article / other material J-STAGE Advance published date: 25 December 2021
doi.org/10.1266/ggs.21-00054Title of the paper MEIOSIN directs initiation of meiosis and subsequent
meiotic prophase program during spermatogenesisJournal article / other material iScience 25, 104008, April 15, 2022 a 2022 The Author(s).
doi.org/10.1016/j.isci.2022.104008Title of the paper FBXO47 is essential for preventing the synaptonemal complex from premature disassembly in mouse male meiosis Journal article / other material Sexual Development
DOI: 10.1159/000520682Title of the paper Sexually Dimorphic Properties in Meiotic Chromosome Journal article / other material Current Topics in Developmental Biology 151, 1-26 (2023) DOI: 10.1016/bs.ctdb.2022.04.0 Title of the paper Mechanism of initiation of meiosis in mouse germ cells Journal article / other material iScience 25 (4), 104008 (2022) doi.org/10.1016/ j.isci.2022.104008 Title of the paper FBXO47 is essential for preventing the synaptonemal complex from premature disassembly in mouse male meiosis Journal article / other material Sexual Development 1-11 (2022) doi:10.1159/000520682 Title of the paper Sexually dimorphic properties in meiotic chromosome Title of the research project A chemical genetics approach to identify direct substrates of Alzheimer’s disease-associated kinase MARK4 in neurons Recipient (Institution) Kanae Ando (Graduate school of science, Department of Biological Sciences, Tokyo Metropolitan University) Journal article / other material Brain Commun. 2024 Apr 17;6(3):fcae136. doi: 10.1093/braincomms/fcae136. PMID: 38712317 Title of the paper Mark4 ablation attenuates pathological phenotypes in a mouse model of tauopathy Journal article / other material Genes Cells. 2024 Apr;29(4):337-346. doi: 10.1111/gtc.13101. Title of the paper Microtubule-affinity regulating kinase family members distinctively affect tau phosphorylation and promote its toxicity in a Drosophila model Journal article / other material Neurobiol Dis. 2023 Nov;188:106334. doi: 10.1016/j.nbd.2023.106334. Title of the paper A cell-penetrating peptide derived from SARS-CoV-2 protein Orf9b allosterically inhibits MARK4 activity and mitigates tau toxicity Journal article / other material eLife, https://doi.org/10.7554/eLife.95576.1 Title of the paper Axonal distribution of mitochondria maintains neuronal autophagy during aging via eIF2β Title of the research project Glial control of behavioral disorders induced by social distancing Recipient (Institution) Ko Matsui (Graduate School of Life Sciences, Super-network Brain Physiology, Tohoku University) Journal article / other material eLife (2024) , 13: RP93721. doi.org/10.7554/eLife.93721.3 Title of the paper Plastic vasomotion entrainment Journal article / other material Neuroscience Research (2023), 202: 39-51. doi.org/10.1016/j.neures.2023.11.008 Title of the paper Glial tone of aggression Journal article / other material Glia(2023) , 71: 2401-2417. doi.org/10.1002/glia.24431 Title of the paper Glial modulation of the parallel memory formation Journal article / other material Brain(2023), 146: 576-586. doi.org/10.1093/brain/awac355 Title of the paper Local brain environment changes associated with epileptogenesis Journal article / other material Nature Neuroscience(2022) , 25, 1458-1469. doi.org/10.1038/s41593-022-01184-5 Title of the paper Glial modulation of the parallel memory formation Title of the research project Genome wide analysis of DNA methylation and transcription dynamics in ICF syndrome Recipient (Institution) William Addison（Division of Molecular Signaling and Biochemistry, Kyushu Dental University） Journal article / other material FASEB J. 2022;36:e22153. doi.org/10.1096/fj.202101402R Title of the paper Inhibition of TET- mediated DNA demethylation suppresses osteoblast differentiation Title of the research project Exploration of pharmaceutical resources based on rapid synthesis and machine learning analysis of optically active compounds Recipient (Institution) Shinobu Takizawa（The Institute of Scientific and Industrial Research, Osaka University） Journal article / other material Organic & Biomolecular Chemistry, 2022, 20, 65586561,
doi: 10.1039/d2ob00940dTitle of the paper DAST-mediated ring-opening of cyclopropyl silyl ethers in nitriles: facile synthesis of allylic amides via a Ritter-type process Journal article / other material Chemical Communications, 2023, 59, 9956, doi: 10.1039/d3cc02719h Title of the paper Light-controlled pKa value of chiral Brønsted acid catalysts in enantioselective aza-Friedel–Crafts reaction Title of the research project Development of Protein Ligand Library for Stereodivergent Synthesis Recipient (Institution) Nobutaka Fujieda（Graduate School of Life and Environmental Sciences, Biophysical Chemistry, Osaka Prefecture University） Journal article / other material Chem. Sci., 14, 3932-3937 (2023). doi.org/10.1039/D2SC06809E Title of the paper An Artificial Metallolyase with Pliable 2-His-1-Carboxylate Facial Triad for Stereoselective Michael Addition Title of the research project Development of novel GVHD mechanism and therapy targeting metabolic disturbance of intestinal epithelial cells that leads to dysbiosis. Recipient (Institution) Hideaki Fujiwara（Department of Hematology and Oncology, Okayama University Hospital） Journal article / other material NATuRe IMMuNOLOgY VOL 22 NOV.2021
doi.org/10.1038/s41590-021-01048-3Title of the paper Mitochondrial complex II in intestinal epithelial cells regulates T cell-mediated immunopathology Journal article / other material Frontiers in Immunolog August 2021, Volume 12 Article 703298
doi: 10.3389/fimmu.2021.703298Title of the paper Crosstalk Between Intestinal Microbiota Derived Metabolites and Tissues in Allogeneic Hematopoietic Cell Transplantation Title of the research project Development of supramolecular hydrogel that enable drug delivery into central nervous system Recipient (Institution) Shinya Kimura（Development of pharmaceutical chemistry, Meiji Pharmaceutical University） Journal article / other material Chem Asian J. 2021, 16, 1937 - 1941
doi.org/10.1002/asia.202100376Title of the paper Enzymatic Hydrolysis-Responsive Supramolecular Hydrogels Composed of Maltose-Coupled Amphiphilic Ureas Journal article / other material Chem Asian J. 2021, 16, 1750 - 1755
doi.org/10.1002/asia.202100433Title of the paper Effect of Alkyl Chain Length of N-Alkyl-N’-(2-benzylphenyl)ureas on Gelation Journal article / other material Chem. Pharm. Bull. 69, 1131-1135 (2021) doi.org/10.1248/cpb.c21-00539 Title of the paper Formation of pH-Responsive Supramolecular Hydrogels in Basic Buffers:Self-assembly of Amphiphilic Tris-Urea Journal article / other material Chem. Pharm. Bull. 70, 443-447 (2022)
doi.org/10.1248/cpb.c22-00134Title of the paper Multiple Stimuli-Responsive Supramolecular Gel Formed from Modified Adenosine Journal article / other material Asian Journal of Organic Chemistry、2022、11、e202200534.
doi.org/10.1002/ajoc.202200534Title of the paper Simple Strategy for Benzo[de]chromene-7,8-dione Synthesis via Tandem Sonogashira Coupling and Intramolecular Cyclization Reactions Journal article / other material Chemical and Pharmaceutical Bulletin、2023、71、229-233.
doi.org/10.1248/cpb.c22-00758Title of the paper Bovine Serum Albumin Hydrogel Formation: pH Dependence and Rheological Analyses Journal article / other material The Journal of Organic Chemistry、2023、88、8714–8721. doi.org/10.1021/acs.joc.3c00598 Title of the paper Simple Strategy for Benzo[g]chromene Synthesis via a Photochemical Intramolecular Cyclization Reaction Title of the research project Understanding of the molecular mechanisms that regulate production of neuronal diversity Recipient (Institution) Takumi Suzuki（laboratory of developmental biology, Ibaraki University, Assistant Professor） Journal article / other material Fly, 2022, 16, 222-232,
doi.org/10.1080/19336934.2022.2073158Title of the paper Cutting edge technologies expose the temporal regulation of neurogenesis in the Drosophila nervous system Title of the research project Unraveling the pathophysiology of AKI to CKD transition by integrating single cell RNA sequencing and lipidomic analyses Recipient (Institution) Takeshi Yamamoto (Blood Purification Center, Osaka University Hospital) Journal article / other material J Am Soc Nephrol . 2024 May 31. doi: 10.1681/ASN.0000000000000414 Title of the paper MondoA and AKI and AKI-to-CKD Transition Title of the research project Identification of the molecular mechanisms in the microbes enhanced oogenesis Recipient (Institution) Ritsuko Suyama ( Graduate School of Frontier Biosciences, Osaka university ) Journal article / other material Communications biology 2023, 6:1287 doi.org/10.1038/s42003-023-05660-x Title of the paper Microbes control Drosophila germline stem cell increase and egg maturation through hormonal pathways Title of the research project Investigation of hepatic metabolic homeostasis and its deterioration by physiological and bioinformatic analyses of vagus nerve-mediated organ-crosstalk Recipient (Institution) Hiroshi Inoue（Metabolism and Nutrition Research Unit, Institute for Frontier Science Initiative, Kanazawa University, Professor） Journal article / other material Nat Commun. 2023 Jan 23;14(1):167.
doi.org/10.1038/s41467-023-35804-wTitle of the paper The transcription factor ATF3 switches cell death from apoptosis to necroptosis in hepatic steatosis in male mice.
- FY2019 Grant Recipients
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Title of the research project Evolution of membrane morphogenesis in Asgard archaea Recipient (Institution) Yosuke Senju（Research Institute for Interdisciplinary Science (RIIS),Okayama University） Journal article / other material Springer Science+Business Media, LLC, part of Springer Nature 2021
doi.org/10.1007/978-1-0716-1142-5_14,Title of the paper Liposome Co-sedimentation and Co-flotation Assays to Study Lipid-Protein Interactions Title of the research project Effects of carbon beam irradiation on connexin and sympathetic nerve expressions and antiarrhythmic effect in rabbits with atrial Recipient (Institution) Mari Amino（Department of Cardiovascular Medicine,Tokai University,Assistant Professor） Journal article / other material Circulation Journal
doi: 10.1253/circj.CJ-22-0527Title of the paper Heavy Ion Irradiation Reduces Vulnerability to Atrial Tachyarrhythmias ― Gap Junction and Sympathetic Neural Remodeling ― Title of the research project Identification of premalignant gastric glands in chronic gastritis mucosa and prophylactics for gastric cancer development. Recipient (Institution) Takahiro Shimizu（Endoscopy Unit,Kyoto University Hospital） Journal article / other material Cancer Research, 2022, 82(9), 1712-1723,
doi: 10.1158/0008-5472.CAN-21-1523Title of the paper Expansion of Gastric Intestinal Metaplasia with Copy Number Aberrations Contributes to Field Cancerization Title of the research project Mechanism of inflammatory memory in hematopoietic stem cell using informatics unifying multidimensional single cell data Recipient (Institution) Hitoshi Takizawa（International Research Center for Medical Sciences (IRCMS),Kumamoto University,Professor） Journal article / other material Front Immunol 2020 Nov 24. doi: 10.3389/fimmu.2020.585367 Title of the paper Immuno-Modulation of Hematopoietic Stem and Progenitor Cells in Inflammation Title of the research project Molecular mechanisms of mycobacterial effector protein for the development of novel anti-TB drugs Recipient (Institution) Giichi Takaesu（Molecular Microbiology Group, Tropical Biosphere Research Center, University of the Ryukyus） Journal article / other material FASEB Journal, 2022, Volume 36, Issue 1, e22096,
doi: 10.1096/fj.202101074RRTitle of the paper GRIM-19 is a target of mycobacterial Zn(2+) metalloprotease 1 and indispensable for NLRP3 inflammasome activation Title of the research project Functional mechanisms and dynamics of oxytocin in autism spectrum disorder Recipient (Institution) Teruhiro Okuyama（Institute for Quantitative Biosciences (IQB),The University of Tokyo） Journal article / other material bioRxiv June 25, 2021
doi.org/10.1101/2021.06.25.449869;Title of the paper Disrupted social memory ensembles in the ventral hippocampus underlie social amnesia in autism-associated Shank3 mutant mice Journal article / other material Current Opinion in Neurobiolog, June 2021
doi.org/10.1016/j.conb.2020.12.008Title of the paper Distinct functions of ventral CA1 and dorsal CA2 in social memory Journal article / other material Development, Growth & Differentiation, December 2020
DOI: 10.1111/dgd.12697Title of the paper Diverse sensory cues for individual recognition Journal article / other material Molecular Psychiatry, in press Title of the paper Disrupted social memory ensembles in the ventral hippocampus underlie social amnesia in autism-associated Shank3 mutant mice Title of the research project Fasting Specific Metabolic Regulation by the Circadian Clock Recipient (Institution) Kenichiro Kiuchi（School of Medicine,Keio University,） Journal article / other material Mol Aspects Med. 2021 Aug;80:100984.
doi: 10.1016/j.mam.2021.100984. Epub 2021 Jun 20.Title of the paper Circadian rhythms in the tissue-specificity from metabolism to immunity: insights from omics studies Title of the research project Cell senescence effects on transcriptional regulation and differentiation in beige preadipocytes Recipient (Institution) Kenji Ikeda（Department of Molecular Endocrinology and Metabolism,Tokyo Medical and Dental University） Journal article / other material Front Endocrinol (Lausanne). 2020 Jul 28; 11: 498
doi: 10.3389/fendo.2020.00498Title of the paper UCP1 Dependent and Independent thermogenesis in Brown and Beige Adipocytes Title of the research project Development of Planar Chiral Cyclic (Amino)(ferrocenyl)carbene Ligands for Medicinal Chemistry Recipient (Institution) Kazuhiro Yoshida（Department of Chemistry, Graduate School of Science, Chiba University） Journal article / other material Adv. Synth. Catal. 2021, 363, 1662-1671
doi :10.1002/adsc.202001419Title of the paper Enantioselective Desymmetrization of 1,3‐Disubstituted Adamantane Derivatives via Rhodium‐Catalyzed C-H Bond Amination: Access to Optically Active Amino Acids Containing Adamantane Core Journal article / other material J. Org. Chem. 2022, 87, 3007-3013 doi :10.1021/acs.joc.1c02836 Title of the paper Chiral Bicyclic NHC/Rh Complexes and Their Application to Catalytic Asymmetric Ring-Opening Reaction of Oxabenzonorbornadienes with Amines Title of the research project Molecular mechanism underlying development of memory-like Group 2 innate lymphoid cells Recipient (Institution) Takashi Ebihara（Department of Medical Biology,Akita University Graduate School of Medicine） Journal article / other material Cells 2020, 9, 1193;
doi:10.3390/cells9051193Title of the paper Dichotomous Regulation of Acquired Immunity by Innate Lymphoid Cells Journal article / other material Allergology International 70 (2) 2021, 174-180
doi.org/10.1016/j.alit.2020.11.007Title of the paper Trained innate lymphoid cells in allergic diseases Journal article / other material J Exp Med (2023) 220 (7): e20222005. doi.org/10.1084/jem.20222005 Title of the paper TIGIT mediates activation-induced cell death of ILC2s during chronic airway allergy Title of the research project Development of urolithiasis therapy by immune response and repair mechanism Recipient (Institution) Takahiro Yasui（Graduate School of Medicine, Nagoya City University） Journal article / other material Front Immunol. 2021 May 24;12:673690. doi: 10.3389/fimmu.2021.673690. eCollection 2021 Title of the paper Macrophage Function in Calcium Oxalate Kidney Stone Formation: A Systematic Review of Literature Title of the research project The model chicken of cardiac septum defect； A new tool for analysis of structural heart disease Recipient (Institution) Saori Matsuhana（Department of Biology, Graduate School of Science, Kobe University） Journal article / other material Cells & Development、2021、167、 203725-203725、
doi :10.1016/j.cdev.2021.203725Title of the paper Identification of regulatory elements for MafB expression in the cardiac neural crest Journal article / other material Developmental Biology、2023、495、1-7
doi:10.1016/j.ydbio.2022.12.006Title of the paper The cardiac neural crest gene MafB ectopically directs CXCR4 expression in the trunk neural crest Title of the research project In vivo Imaging of Brain in CNS Lupus Defines Unique Roles for Chemoattractants Recipient (Institution) Yoshishige Miyabe（Institute for Advanced Medical Sciences,Nippon Medical School） Journal article / other material JMA J. 2020;3(3):
DOI: 10.31662/jmaj.2020-0019Title of the paper Targeting the Chemokine System in Rheumatoid Arthritis and Vasculitis Title of the research project Elucidating the system to generate dormancy that confer chemotherapy-resistance to cancer cells Recipient (Institution) Keisuke Nimura（Division of Gene Therapy Science,Osaka University,Associate Professor） Journal article / other material Cancers 2022, 14, 3580
doi: 10.3390/cancers14153580.Title of the paper Identification of Malignant Cell Populations Associated with Poor Prognosis in High-Grade Serous Ovarian Cancer Using Single-Cell RNA Sequencing Title of the research project Mechanism and targeting therapy for TGF pathway-dependent diffuse-type gastric cancer Recipient (Institution) Yoku Hayakawa（Department of Gastroenterology,The University of Tokyo Hospital,） Journal article / other material Cell Stem Cell 28, August 5, 2021
https://doi.org/10.1016/j.stem.2021.05.012Title of the paper Stem cells and origins of cancer in the upper gastrointestinal tract Title of the research project Mechanisms involved in regulation of osteoclast formation by glucan recognition via immune receptors Recipient (Institution) Wataru Ariyoshi（Division of Infections and Molecular Biology,Kyushu Dental University） Journal article / other material Molecules 2021, 26, 1982
doi.org/10.3390/molecules26071982Title of the paper Biological Effects of β-Glucans on Osteoclastogenesis Title of the research project Elucidation of the promotion mechanism in plant shoot regeneration by environmental stimuli Recipient (Institution) Sachihiro Matsunaga（Matsunaga Laboratory, Department of Applied Biological Science, Faculty of Science and Technology,Tokyo University of Science） Journal article / other material NATURE COMMUNICATIONS (2020) 11:5914
doi.org/10.1038/s41467-020-19621-zTitle of the paper Subnuclear gene positioning through lamina association affects copper tolerance Journal article / other material Communications biology 14, May 2021
doi.org/10.1038/s42003-021-02106-0Title of the paper A live imaging system to analyze spatiotemporal dynamics of RNA polymerase II modification in Arabidopsis thaliana Title of the research project Analyses of pain regulation mechanisms by IL-27 Recipient (Institution) Hiroki Yoshida（Dept Biomol Sci, Faculty of Medicine,Saga University,Professor） Journal article / other material Microbiol Spectr. 2021 Aug 4;e0051121.
doi: 10.1128/Spectrum.00511-21Title of the paper Entamoeba Chitinase is Required for Mature Round Cyst Formation Title of the research project Molecular and neural mechanism associated with social behavior Recipient (Institution) Teiichi Furuichi（Department of Biological Science, Faculty of Science and Technology,Tokyo University of science） Journal article / other material Front. Cell. Neurosci. 2020, 14: 595607.
doi: 10.3389/fncel.2020.595607.Title of the paper Comprehensive Profiling of Gene Expression in the Cerebral Cortex and Striatum of BTBRTF/ArtRbrc Mice Compared to C57BL/6J Mice. Journal article / other material Cell Tissue Res. 2020, 382(1):125-134.
doi: 10.1007/s00441-020-03274-x.Title of the paper Journey of brain-derived neurotrophic factor: from intracellular trafficking to secretion Journal article / other material The Journal of Neuroscience, May 19, 2021
doi.org/10.1523/JNEUROSCI.3240-20.2021Title of the paper CAPS2 Deficiency Impairs the Release of the Social Peptide Oxytocin, as Well as Oxytocin-Associated Social Behavior Journal article / other material Frontiers in Molecular Biosciences, 2022, 9:1040237
Doi: 10.3389/fmolb.2022.1040237Title of the paper Loss of CAPS2/Cadps2 leads to exocrine pancreatic cell injury and intracellular accumulation of secretory granules in mice Title of the research project Development of H2S-Activatable Near-Infrared-dye Probes: Bioimaging and Therapy Recipient (Institution) Yusuke Ishigaki（Laboratory of Organic Chemistry Ⅰ, Department of Chemistry,Hokkaido University） Journal article / other material Chem. Commun. 2021, 57, 7201-7214. DOI: 10.1039/D1CC02260A Title of the paper Redox-active Tetraaryldibenzoquinodimethanes Title of the research project Identification of molecular mechanism underlying drug resistance by tumor-stroma derived exosome Recipient (Institution) Takatsugu Ishimoto（Division of Translational Research and Advanced Treatment Against Gastrointestinal Cancer,Kumamoto University Hospital） Journal article / other material Cancer Res. 2020; 80(16): 3222-3235
doi: 10.1158/0008-5472.CAN-19-3803Title of the paper Extracellular Vesicles from Cancer-Associated Fibroblasts Containing Annexin A6 Induces FAK-YAP Activation by Stabilizing b1 Integrin, Enhancing Drug Resistance Title of the research project The ultrastabilization mechanism of amyloid revealed by a protein engineering technique Recipient (Institution) Koki Makabe（School of science and engineering, Makabe lab.,Yamagata university） Journal article / other material 2021 Wiley Periodicals LLC, 8 February 2021
DOI: 10.1002/prot.26063Title of the paper Structural analysis of the β-sheet edge of peptide self-assembly using a model protein Title of the research project Identification of the lipid species which regulate epidermis differentiation in Arabidopsis Recipient (Institution) Mitsutomo Abe（Graduate School of Arts and Sciences,The University of Tokyo） Journal article / other material The Company of Biologists, Development (2021) 148, dev194969. doi:10.1242ldev.194969 Title of the paper Ceramides mediate positional signals in Arabidopsis thaliana protoderm differentiation - FY2018 Grant Recipients
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Title of the research project Fundamental study for GATA3 transcriptional complex and new insight into functional role of type2 innate lymphoid cells to control life-style related disease Recipient (Institution) Tanaka Tomoaki（Chiba University, Graduate School Medicine） Journal article / other material eNeurologicalSci. 19:100239, 2020
10.1016/j.ensci.2020.100239Title of the paper Monoamine oxidase B rs1799836 G allele polymorphism is a risk factor for early development of levodopa-induced dyskinesia in Parkinson's disease. Journal article / other material Endcrine Journal. 67(8):841-852 2020.
doi.org/10.1507/endocrj.EJ19-0617Title of the paper A multicenter, phase 2 study to evaluate the efficacy and safety of osilodrostat, a new 11β-hydroxylase inhibitor, in Japanese patients with endogenous Cushing’s syndrome other than Cushing’s disease. Journal article / other material J Clin Endocrinol Metab., Epub., 105(2): dgz073, 202
DOI:10.1210/clinem/dgz073Title of the paper A case of Hashimoto’s thyroiditis with multiple drug resistance and high expression of efflux transporters. Title of the research project Importance of tissue-resident memory T cells in mucosal tissue Recipient (Institution) Iijima Norifumi（National Institutes of Biomedical Innovation, Health and Nutriti） Journal article / other material Curr Top Microbiol Immunol. 2020, 426, 83
10.1007/82_2020_213.Title of the paper Memory Lymphocyte Clusters in Genital Immunity: Role of Tissue-Resident Memory T Cells (TRM). Journal article / other material Neurochemical Research. 2021 Jul 1.
doi: 10.1007/s11064-021-03384-0.Title of the paper Distinct expression of SLM2 underlies splicing-dependent trans-synaptic signaling of neurexin across GABAergic neuron subtypes Title of the research project Analysis of cell lineage and transcriptional regulation during ventricular development of heart Recipient (Institution) Watanabe Yusuke（Molecular Phys lab, National Cerebral and Cardiovascular Center） Journal article / other material Dev Biol. 2020;461(2):124-131.
doi: 10.1016/j.ydbio.2020.02.001.Title of the paper Expression of Hey2 transcription factor in the early embryonic ventricles is controlled through a distal enhancer by Tbx20 and Gata transcription factors Journal article / other material J Biol Chem. 2020;295(51):17632-17645.
doi: 10.1074/jbc.RA120.015003.Title of the paper Importance of endothelial Hey1 expression for thoracic great vessel development and its distal enhancer for Notch-dependent endothelial transcription Journal article / other material Dev Growth Differ. 2021;63(1):82-92.
doi: 10.1111/dgd.12707.Title of the paper A role of Hey2 transcription factor for right ventricle development through regulation of Tbx2-Mycn pathway during cardiac morphogenesis Title of the research project Pathophysiologic role of a novel microenvironment that prolongs tissue damage in acute kidney injury Recipient (Institution) Suganami Takayoshi（Dept. of Molecular Medicine and Metabolism, Nagoya University） Journal article / other material J Exp Med. 2020; 217: e20192230
doi: 10.1084/jem.20192230.Title of the paper C-type lectin Mincle mediates cell death-triggered inflammation in acute kidney injury. Title of the research project Development of new base editor systems Recipient (Institution) Yachie Nozomu（RCAST, The University of Tokyo） Journal article / other material Nature Biotechnology 38, 865-869 (2020)
doi.org/10.1038/s41587-020-0509-0Title of the paper Base editors for simultaneous introduction of C-to-T and A-to-G mutations. Title of the research project Study on the circadian rhythm system regulated by intracellular carbon monoxide Recipient (Institution) Kitagishi Hiroaki（Faculty of Science and Engineering, Doshisha University） Journal article / other material Chem.Asia J. 2019.14.3320-3328
doi.org/10.1002/asia.201900983Title of the paper Supramolecular Complexation in Biological Media: NMR Study on Inclusion of an Anionic Tetraarylporphyrin into a Per‐O ‐Methylated β‐Cyclodextrin Cavity in Serum, Blood, and Urine Journal article / other material Communications Biology, 4, 425 (2021) (15 pages)
DOI: 10.1038/s42003-021-01880-1Title of the paper Sensitive quantification of carbon monoxide (CO) in vivo reveals a protective role of circulating hemoglobin in CO intoxication Journal article / other material Polymer Journal volume 54, pages 465-472 (2022)
DOI: 10.1038/s41428-021-00591-yTitle of the paper Capture of carbon monoxide using a heme protein model: from biomimetic chemistry of heme proteins to physiological and therapeutic applications Title of the research project The RNA-based mechanism underlying pathophysiology in the neurological diseases Recipient (Institution) Iijima Takatoshi（Tokai University Institute of Innovative Science and Technology） Journal article / other material Neurochemical Research (in revision) Title of the paper Distinct expression of SLM2 underlies splicing-dependent trans-synaptic signaling of neurexin across GABAergic neuron subtypes Journal article / other material iScience. 22:318-335. (2019)
doi: 10.1016/j.isci.2019.11.028.Title of the paper SAM68-Specific Splicing Is Required for Proper Selection of Alternative 3' UTR Isoforms in the Nervous System. Title of the research project Elucidation of the molecular basis and physiological significance of autophagic degradation of the nuclear pore complex Recipient (Institution) Nakatogawa Hitoshi（Sch. of Life Sci. and Tech., Tokyo Institute of Technology） Journal article / other material Journal of Cell Biology (2020) 219, 7, e201910063
doi.org/10.1083/jcb.201910063Title of the paper TORC1 inactivation stimulates autophagy of nucleoporin and nuclear pore complexes Title of the research project Identification of glycosyltransferases involved in biosynthesis of pectin in plant cell wall Recipient (Institution) Ishimizu Takeshi（Dept. of Biotechnol., Col. of Life Sci., Ritsumeikan Univ.） Journal article / other material Plant Physiology and Biochemistry (2019) 142, 173-178
10.1016/j.plaphy.2019.07.008Title of the paper Rhamnogalacturonan I galactosyltransferase: Detection of enzyme activity and its hyperactivation Journal article / other material Frontiers in Plant Science (2020) 11, 997
10.3389/fpls.2020.00997Title of the paper Diversity of Pectin Rhamnogalacturonan I Rhamnosyltransferases in Glycosyltransferase Family 106 Journal article / other material Journal of the Japanese Society of Applied Glycoscience (2020) 10, 96-102
doi.org/10.5458/bag.10.2_96Title of the paper Toward the Elucidation of Molecular Mechanism for Biosynthesis of Pectin in Plant Cell Wall Title of the research project RNA base modification and RNA processing regulate the maintenance and development of germline stem cells Recipient (Institution) Kai Toshie（Graduate School of Frontier Biosciences, Osaka University） Journal article / other material PLOS ONE、2020、Vol.15、e0231114
10.137/journal.pone.0231114Title of the paper Drosophila MARF1 ensures proper oocyte maturation by regulating nanos expression Journal article / other material Cell Reports、2020、10;33(6):108380、
doi: 10.1016/j.celrep.2020.108380Title of the paper Modulation of Ago2 Loading by Cyclophilin 40 Endows a Unique Repertoire of Functional miRNAs during Sperm Maturation in Drosophila Title of the research project Unveiling a novel regulatory mechanism of angiogenesis by intraluminal pressure Recipient (Institution) Fukuhara Shigetomo（Inst. of Adv. Med. Sci., Nippon Medical School, Professor） Journal article / other material Kidney360 April 2022, 3 (4) 700-713
DOI: https://doi.org/10.34067/KID.0005962021Title of the paper Blood flow regulates glomerular capillary formation in zebrafish pronephros. Journal article / other material Nat. Commun. 2022 May 12;13(1):2594.
doi: 10.1038/s41467-022-30197-8.Title of the paper Mechanical loading of intraluminal pressure mediates wound angiogenesis by regulating the TOCA family of F-BAR proteins. Title of the research project Physiological roles and molecular mechanisms underlying the synaptic plasticity in the dentate gyrus Recipient (Institution) Hashimotodani Yuki（Doshisha University, Organization for Research Initiatives and Development） Journal article / other material Proceedings of the National Academy of Sciences of the United States of America 119(13) e2119636119 2022年/ doi.org/10.1073/pnas.2119636119 Title of the paper Excitatory selective LTP of supramammillary glutamatergic/GABAergic cotransmission potentiates dentate granule cell firing Title of the research project The role of desmoplakin in the antidepressant-like effects in the hippocampus Recipient (Institution) SegiNishida Eri（Segi lab, Dept. of Biol. Sci. and Tech., Tokyo University of Sci） Journal article / other material Pharmacol Biochem Behav. 186:172767. 2019.
10.1016/j.pbb.2019.172767Title of the paper Search for factors contributing to resistance to the electroconvulsive seizure treatment model using adrenocorticotrophic hormone-treated mice. Journal article / other material Neuropsychopharmacol Rep. 41:56-64.2021
10.1002/npr2.12156Title of the paper Electroconvulsive seizures lead to lipolytic-induced gene expression changes in mediobasal hypothalamus and decreased white adipose tissue mass. Title of the research project Identification and molecular mechanism of novel calcium transport disease ;possible therapeutic target for bone mineralization defects Recipient (Institution) Suzuki Yoshiro（Div. Cell Signaling, Nat. Inst. Physiol. Sci.） Journal article / other material J Physiol Sci (2020) 70(1) 33 - 33
10.1186/s12576-020-00761-2Title of the paper Novel TRPV6 mutations in the spectrum of transient neonatal hyperparathyroidism Title of the research project Projection-specific circuit formation in the developing cerebral cortex Recipient (Institution) Tagawa Yoshiaki（Dept. Physiology, Faculty of Medicine, Kagoshima University） Journal article / other material Cerebral Cortex, 2021, 31, 1307-1315
doi:10.1093/cercor/bhaa297Title of the paper Long-range interhemispheric projecion neurons show biased Journal article / other material Frontiers in Neuroscience, 2021, 15, Article 747951,
doi: 10.3389/fnins.2021.747951Title of the paper Involvement of Calcium-Dependent Pathway and β Subunit-Interaction in Neuronal Migration and Callosal Projection Deficits Caused by the Cav1.2 I1166T Mutation in Developing Mouse Neocortex Title of the research project Peptide foldamers in drug discovery Recipient (Institution) Demizu Yosuke（Division of Organic Chemistry, NIHS） Journal article / other material ChemMedChem,14,22（2019)
doi.org/10.1002/cmdc.201900460Title of the paper Development of Amphipathic Antimicrobial Peptide Foldamers Based on Magainin 2 Sequence Journal article / other material MedChemComm,10,6,831-1044（2019）
doi.org/10.1039/c9md00166bTitle of the paper Rational design of novel amphipathic antimicrobial peptides focused on the distribution of cationic amino acid residues Title of the research project Research on metabolic reprogramming induced by cancer development and inflammation Recipient (Institution) Taniguchi Koji（Department of Microbiology and Immunology, Keio University） Journal article / other material Mol Cancer Res 2020 18(12):1876-1888.
doi: 10.1158/1541-7786.MCR-20-0186Title of the paper Autocrine Leukemia Inhibitory Factor Promotes Esophageal Squamous Cell Carcinoma Progression via Src Family Kinase-Dependent Yes-Associated Protein Activation Title of the paper Int J Mol Sci. 2021 Feb 24;22(5):2238.
doi: 10.3390/ijms22052238.Journal article / other material Immunomodulation by Inflammation during Liver and Gastrointestinal Tumorigenesis and Aging Title of the paper Int J Mol Sci. 2021 May 21;22(11):5421.
doi: 10.3390/ijms22115421.Journal article / other material Inflammation-Induced Tumorigenesis and Metastasis - FY2017 Grant Recipients
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Title of the research project Epigenetic and Metabolic Changes on transdifferentiation of white adipocytes Recipient (Institution) Takeshi Inagaki（Institute for Molecular and Cellular Regulation, Gunma University, professor） Journal article / other material Endocrine Journal vol.66,No2(February 2019)
Published by The Japan Endocrine SocietyTitle of the paper Epigenetic regulation of beige adipocyte fate by histone methylation Journal article / other material Diabetology International(2018) 9:215-223 Title of the paper Histone demethylases regulate adipocyte thermogenesis Title of the research project Neural circuits that regulate glucose metabolism between hypothalamus and peripheral organs Recipient (Institution) Kunio Kondoh（National Institute for Physiological Sciences, Assistant Professor ） Journal article / other material Neuroscience Bulletin,20 September 2018
doi:/10.1007/s12264-019-00374-9Title of the paper Trans-synaptic Neural Circuit-Tracing with Neurotropic Viruses Title of the research project Heart Cell Molecular Atlas Project to dissect the regulatory mechanisms of circulatory homeostasis Recipient (Institution) Seitaro Nomura（The University of Tokyo Hospital, Assistant Professor） Journal article / other material Nature Communications volume 9, Article number: 4435 (2018) Title of the paper Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure Journal article / other material Journal of Molecular and Cellular Cardiology,
March 2019Volume 128, Pages 77-89Title of the paper High-throughput single-molecule RNA imaging analysis reveals heterogeneous responses of cardiomyocytes to hemodynamic overload Title of the research project Study on the enantioselective total synthesis of dragmacidin E: a natural product with high potential for medicinal chemistry researches Recipient (Institution) Tetsuhiro Nemoto（Graduate School of Pharmaceutical Sciences, Chiba University, Professor） Journal article / other material ASIAN JOURNAL OF ORGANIC CHEMISTRY Vol.7,2018,P1730-1742 Title of the paper Synthetic Methods for 3,4‐Fused Tricyclic Indoles via Indole Ring Formation Title of the research project Development of combination therapy targeting on tumor endothelial cells Recipient (Institution) Takahisa Murata（The University of Tokyo, Associate Professor） Journal article / other material THE FASEB JOURNAL,vol33 doi/10.1096/201802153R Title of the paper Hematopoietic prostaglandin D synthase-derived prostaglandin D2 ameliorates adjuvant-induced joint inflammation in mice Journal article / other material JCI Insight. 2018;3(23):e120706,doi/10.1172 Title of the paper Inhibition of stromal cell-derived factor-1α/CXCR4 signaling restores the blood-retina barrier in pericyte-deficient mouse retinas Journal article / other material The journal of pathology ,2019,Vol.248(3),p.280-290 Title of the paper L-PGDS-derived PGD2attenuates acute lung injury by enhancing endothelial barrier formation Title of the research project Development of super resolution chemical imaging microscopy Recipient (Institution) Takahashi Yasufumi（Kanazawa University） Journal article / other material Analytical Chemistry, 2021, 93(13), 5383-5393
doi.org/10.1021/acs.analchem.0c04097Title of the paper Nanoscale Visualization of Morphological Alteration of Live-Cell Membranes by the Interaction with Oligoarginine Cell-Penetrating Peptides Journal article / other material Analytical Chemistry, 2020, 92(2), 2159-2167
doi.org/10.1021/acs.analchem.9b04775Title of the paper High-Speed SICM for the Visualization of Nanoscale Dynamic Structural Changes in Hippocampal Neurons Title of the research project Exploratory analysis to evaluate mutation spectrum of circulating tumor DNA from metastatic breast cancer treated with aromatase inhibitors Recipient (Institution) SiewKee Low（Japanese Foundation for Cancer Research） Journal article / other material Breast Cancer Res Treat. 2020 Apr;180(2):331-341.
10.1007/s10549-019-05512-5Title of the paper Clinical significance of gene mutation in ctDNA analysis for hormone receptor-positive metastatic breast cancer Title of the research project Functional Analysis of Chk1 Targets for Breast Cancer Treatment Recipient (Institution) Shimada Midori（Yamaguchi University, Joint Faculty of Veterinary Medicine） Journal article / other material PNAS. 2021; 118: e211425811
doi: 10.1073/pnas.2114258118Title of the paper Calcineurin regulates the stability and activity of estrogen receptor α. Title of the research project Direct reprogramming into cardiac pacemaker cells for a novel regenerative medicine for arrhythmias Recipient (Institution) Nakao Shu（Ritsumeikan University） Journal article / other material Biotechnol J 2019;2019:e1900052
10.1002/biot.201900052Title of the paper Chimeric G-CSF receptor-mediated STAT3 activation contributes to efficient induction of cardiomyocytes from mouse induced pluripotent stem cells. Title of the research project Development of apoptosis induction method with spatiotemporal control using microRNAs. Recipient (Institution) Watanabe Kazunori（Okayama University） Journal article / other material Scientific reports, 2021, 11, 14936 doi 10.1038/s41598-021-94249-7. Title of the paper Photocontrolled apoptosis induction using precursor miR-664a and an RNA carrier-conjugated with photosensitizer Title of the research project Molecular mechanism of store-operated Ca2+ entry signalosome and its physiological significance Recipient (Institution) Baba Yoshihiro（Medical Institute of Bioregulation, Kyushu University） Journal article / other material The Journal of Biochemistry, mvab063, in press
10.1093/jb/mvab063Title of the paper ER membrane protein complex 1 interacts with STIM1 and regulates store-operated Ca2+ entry Title of the research project Decoding the epigenome program which defines normal and tumor endothelial cells Recipient (Institution) Suzuki Hiromu（Sapporo Medical University） Journal article / other material Cancer Science, 2020, 111(5):1631-1644
10.1111/cas.14360.Title of the paper Upregulation of adipocyte enhancer-binding protein 1 in endothelial cells promotes tumor angiogenesis in colorectal cancer. Title of the research project Elucidation of long non-coding RNA family induced by molecular targeting anti-cancer drugs Recipient (Institution) Kondo Shigetada（Osaka Prefecture University） Journal article / other material Neuroscience Bulletin 2019年 33巻 909-920頁
10.1007/s12264-019-00374-9Title of the paper Trans-synaptic Neural Circuit-Tracing with Neurotropic Viruses Title of the research project Development of anti-metastatic therapy based on the regulation of vascular integrity Recipient (Institution) Shindo Takayuki（Shinshu University Graduate School of Medicine） Journal article / other material Peptides. 110 10-18. 2018
10.1016/j.peptides.2018.10.006Title of the paper RAMP3 deficiency enhances postmenopausal obesity and metabolic disorders Journal article / other material Am J Pathol. 189(2):449-466. 2019
10.1016/j.ajpath.2018.10.021Title of the paper Development of a novel model of central retinal vascular occlusion and the therapeutic potential of the adrenomedullin-RAMP2 system Journal article / other material Am J Pathol. 191(4):652-668, 2021
10.1016/j.ajpath.2020.12.012Title of the paper Adrenomedullin-RAMP2 system ameliorates subretinal fibrosis by suppressing epithelial-mesenchymal transition in age-related macular degeneration Title of the research project Mechanisms underlying commitment to thymic epithelial cells preventing onset of autoimmune diseases Recipient (Institution) Akiyama Taishin（RIKEN Center for Integrative Medical Science, Team leader） Journal article / other material Sci Rep. 2019 Dec 27;9(1):19866.
10.1038/s41598-019-56432-9.Title of the paper Impact of spaceflight on the murine thymus and mitigation by exposure to artificial gravity during spaceflight Journal article / other material Sci Rep. 2019 May 21;9(1):7654
10.1038/s41598-019-44067-9Title of the paper Down-regulation of GATA1-dependent erythrocyte-related genes in the spleens of mice exposed to a space travel Title of the research project Regulation of cellular functions by the nuclelous as a stress sensor Recipient (Institution) Kimura Keiji（University of Tsukuba） Journal article / other material Nucleic Acids Research、2020、48、12、6583-6596
10.1093/nar/gkaa449.Title of the paper Identification of a novel nucleolar protein complex required for mitotic chromosome segregation through centromeric accumulation of Aurora B Journal article / other material Biochem Biophys Res Commun. 2022 Jan 15;588:133-139. doi: 10.1016/j.bbrc.2021.12.059. Title of the paper SF3B14 is involved in the centrosome regulation through splicing of TUBGCP6 pre-mRNA Title of the research project Tras-omics approach to elucidate cellular signaling pathways in vascular development, morphogenesis and disease Recipient (Institution) Nakagawa Osamu（National Cerebral and Cardiovascular Center Research Institute） Journal article / other material genesis. 59(4): e23416, 2021.
10.1002/dvg.23416Title of the paper Tmem100-BAC-EGFP mice to selectively mark and purify embryonic endothelial cells of large caliber arteries in mid-gestational vascular formation. Journal article / other material Dev. Growth Differ. 63(1): 82-92, 2021.
10.1111/dgd.12707Title of the paper A role of Hey2 transcription factor for right ventricle development through regulation of Tbx2-Mycn pathway during cardiac morphogenesis Journal article / other material J. Biol. Chem. 295(51):17632-17645, 2020.
10.1074/jbc.RA120.015003Title of the paper Importance of endothelial Hey1 expression for thoracic great vessel development and its distal enhancer for Notch-dependent endothelial transcription. Journal article / other material Genes Cells. 26(8): 611-626, 2021
doi: 10.1111/gtc.12874Title of the paper ETS- dependent enhancers for endothelial- specific expression of Title of the research project Studies on formation and function of extracellular DNA fibers Recipient (Institution) Saitoh Hisato（Kumamoto University） Journal article / other material Sci Rep 9, 8451 (2019).
doi.org/10.1038/s41598-019-44817-9Title of the paper Nanosecond pulsed electric fields induce extracellular release of chromosomal DNA and histone citrullination in neutrophil-differentiated HL-60 cells. Journal article / other material CellBio, 2020, 9, 14-28.
doi: 10.4236/cellbio.2020.91002.Title of the paper Three Types of Nuclear Envelope Assemblies Associated with Micronuclei. Journal article / other material Bioscience, Biotechnology, and Biochemistry, Volume 84, Issue 8, 2 August 2020, Pages 1685-1688,
doi.org/10.1080/09168451.2020.1756737Title of the paper A fluorescence method to visualize the nuclear boundary by the lipophilic dye DiI Title of the research project 5-HT2A receptor agonists in treatment to psychiatric disorders Recipient (Institution) Ibi Daisuke（Meijo University） Journal article / other material Neurotoxicology and Teratology、2019、76、106837
10.1016/j.ntt.2019.106837Title of the paper Paternal valproic acid exposure in mice triggers behavioral alterations in offspring Title of the research project A novel oxytocin neuronal system for regulating lactating behavior in mice Recipient (Institution) Muroi Yoshikage（Obihiro University of Agriculture and Veterinary Medicine） Journal article / other material Hormones and Behavior, 2020, 124, 104773
10.1016/j.yhbeh.2020.104773Title of the paper Oxytocin in the dorsal raphe nucleus antagonizes the inhibition of maternal care induced by food deprivation Journal article / other material Behavioral Neuroscience, 2021, Vol. 135, No. 3, 359-368
doi.org/10.1037/bne0000374Title of the paper Regulation of maternal care by corticotropin-releasing factor receptors in the dorsal raphe nucleus in mice. Title of the research project Molecular mechanism for the bifurcation of thymic epithelial cells Recipient (Institution) Ohigashi Izumi（Institute of Advanced Medical Science, University of Tokushima ） Journal article / other material Cell Reports (2019) 29:2901-2916
doi: 10.1016/j.celrep.2019.10.079Title of the paper Trans-omics impact of thymoproteasome in cortical thymic epithelial cells Journal article / other material Journal of Biological Chemistry (2020) 295:1658-1672
doi: 10.1074/jbc.RA119.011144Title of the paper PITHD1 is a proteasome-interacting protein essential for male fertilization Journal article / other material Blood advances (2021) 5:99-112
doi: 10.1182/bloodadvances.2020003192Title of the paper Medullary stromal cells synergize their production and capture of CCL21 for T-cell emigration from neonatal mouse thymus Journal article / other material eLife (2022) 11:e69088.
doi.org/10.7554/eLife.69088Title of the paper Fine-tuning of β-catenin in mouse thymic epithelial cells is required for postnatal T-cell development Title of the research project Novel treatment strategy targeting CCR1-positive myeloid cells in colorectal cancer Recipient (Institution) Kawada Kenji（Kyoto University） Journal article / other material Clin Cancer Res. 2019;25(9):2887-2899.
10.1158/1078-0432.CCR-18-3684.Title of the paper Loss of SMAD4 promotes colorectal cancer progression by recruiting tumor-associated neutrophils via CXCL1/8-CXCR2 axis Title of the research project Design principle for specific chemical probes toward 3D neuropathology Recipient (Institution) Tainaka Kazuki（Brain Research Institute, Niigata University） Journal article / other material Cell Reports, 2018, 24(8), 2196-2210.e9.
10.1016/j.celrep.2018.07.056.Title of the paper Chemical Landscape for Tissue Clearing Based on Hydrophilic Reagents
- FY2016 Grant Recipients
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Title of the research project Identification of novel neural processing mechanism by using single transcriptome analysis Recipient (Institution) Akane Ohta（Konan University, Researcher） Journal article / other material Cryobiology and Cryotechnology 64.2_53 (2019)
doi./10.20585/Title of the paper Molecular and Cellular Network Systems Underlying Cold Tolerance of Caenorhabditis elegans Title of the research project Genome-wide analysis of transcriptional and translational regulation by RNA binding protein PSF in prostate cancer Recipient (Institution) Kenichi Takayama Department of Functional Biogerontology, Tokyo Metropolitan Inst, Researcher） Journal article / other material Oncogene 37, 2165-2180, (2018)
https://doi.org/10.1038/s41388-017-0095-xTitle of the paper TRIM25 enhances cell growth and cell survival by modulating p53 signals via interaction with G3BP2 in prostate cancer Title of the research project Study on the Mechanism of Sex Determination in Germline Stem Cells Recipient (Institution) Minoru Tanaka（Nagoya University, Professor） Journal article / other material PLOS Genetics 14, (2018)
https://doi.org/10.1371/journal.pgen.1007259Title of the paper Germ cells in the teleost fish medaka have an inherent feminizing effect Title of the research project Elucidation of the onset mechanism of myeloproliferative neoplasm through the erythropoietin receptor Recipient (Institution) Megumi Tago（Keio University, Associate Professor） Journal article / other material European Journal of Pharmacology 825, 1-9, (2018)
https://doi.org/10.1016/j.ejphar.2018.02.012Title of the paper A major component of vitamin E, α-tocopherol inhibits the anti-tumor activity of crizotinib against cells transformed by EML4-ALK Title of the research project Selective information routing in hippocampal network Recipient (Institution) Mizuseki Kenji（Osaka City University Graduate School of Medicine, Professor） Journal article / other material Neuroscience Research 118, 30-47, (2017)
http://dx.doi.org/10.1016/j-neures.2017.04.018Title of the paper Hippocampal information proccessing across sleep/wake cycles
- FY2015 Grant Recipients
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Title of the research project Control of host immune responses through innate pattern-recognition receptors that recognize Mycobacterium tuberculosis virulence lipids Recipient (Institution) Hiromitsu Hara, Kagoshima University Graduate School of Medical and Dental Sciences, Professor Journal article / other material Nature Communications 6:5555
doi:10.1038/ncomms6555Title of the paper Clustering of CARMA1 through SH3-GUK domain interactions is required for its activation of NF-κB signaling Title of the research project Molecular mechanism of plant cell growth via NIMA-related kinases Recipient (Institution) Hiroyasu Motose, Okayama University, Department of Biological Science, Graduate School of Natural Science & Technology, Associate Professor Journal article / other material Development (2018) 145, dev154617
doi:10.1242/dev.154617Title of the paper An evolutionarily conserved NIMA-related kinase directs rhizoid tip growth in the basal land plant Merchantia polymorpha Journal article / other material Scientific Report 7, 7826
doi:10.1038/s41598-017-08453-5Title of the paper Directional cell expansion requires NIMA-related kinase 6 (NEK6)-mediated cortical microtubule destabilization Title of the research project Analysis of a signal through ER required for the induction of axon regeneration Recipient (Institution) Naoki Hisamoto, Nagoya university Graduate school of Science, Associate Professor Journal article / other material PLoS 12(12):e1006475
doi:10.1371/journal.pgen.1006475Title of the paper The C. elegans Discoidin Domain Receptor DDR-2 Modulates the Met-like RTK-JNK Singnaling Pathway in Axon Regeneration Title of the research project Development of molecular delivery system using cell membrane penetrating DNA nanostructures Recipient (Institution) Masayuki Endo, Kyoto University, Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Journal article / other material Chem. Eur. J 23, 3979-3985 (2017)
doi:10.1002/chem.201605616Title of the paper A photoregulated DNA-Based Rotary System and Direct Observation of Its Rotational Movement Title of the research project Functional significance of Chandelier cell in cortical microcircuit Recipient (Institution) Yoshiyuki Kubota, National Institute for Physiological Sciences, Associate professor Journal article / other material Front Neural Circuits 10, 27 (2016)
doi:10.3389/fncir.2016.00027Title of the paper The Diversity of Cortical Inhibitory Synapses Journal article / other material Nat Commun 9, 437 (2018)
doi:10.1038/s41467-017-02768-7Title of the paper A catructurerbon nanotube tape for serial-section electron microscopy of brain ultra Title of the research project Cortical synaptic plasticity for coexistence of chronic pain and anxiety neurosis Recipient (Institution) Kohei Koga, Hirosaki University Department of Neurophysiology, Assistant Journal article / other material J. Neurochem. 141 486-498 (2017) Title of the paper Neuronal and microglial mechanisms for neuropathic pain in the spinal dorsal horn and anterior cingulate cortex Title of the research project Functional analysis of a novel silencing mechanism in higher plants Recipient (Institution) Kei-ichiro Mishiba, Graduate School of Life and Environmental Science, Osaka Prefecture University, Associate Journal article / other material Science Direct 1860, 861-869 (2017)
https:doi.org/10.1016/j.bbagrm.2017.06.001Title of the paper Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms Title of the research project The origin of animal multicellular system an approach from genome editing of unicellular holozoans Recipient (Institution) Hiroshi Suga, Prefectural University of Hiroshima, Faculty of Life and Environmental Sciences, Associate Professor Journal article / other material eLife 2017 6:e26036
doi:10.7554/eLife.26036Title of the paper Dynamics of genomic innovation in the unicellular ancestry of animals Title of the research project Regulating microtubule arrays for neuronal dendrite growth and for neuronal regeneration Recipient (Institution) Adrian Moore（RIKEN Center for Brain Science） Journal article / other material Plant Physiology,182,1979－1990（2020） Title of the paper Atypical Myosin Tunes Dendrite Arbor Subdivision
- FY2014 Grant Recipients
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Title of the research project Effect of dendritic cell based vaccine against highly virulent cryptococcal infection Recipient (Institution) Yuki Kinjo (National Institute of Infectious Diseases, Department of Chemotherapy and Mycoses, LaboratoryHead) Journal article / other material Frontiers in Cellular and infection Microbiology 5:101 Doi: 10.3389/fcimb.2015.00101 (2016) Title of the paper Evasion of innate immune responses by the highly virulent Cryptococcus gatti by altering capsule glucuronoxylomannan structure Journal article / other material J Infect Chemother., 21, 831-6 (2015) Title of the paper Interferon-γ promotes phagocytosis of Cryptococcus neoformans but not Cryptococcus gatti by murine macrophages Journal article / other material Vaccine Design: methods and Protocols: volume 1: vaccines for Human Diseases, method in Molecular Biology, vol 1.1403, DOI 10.1007/978-1-49393387-7_30 Title of the paper Dendric cell-based vaccine against fungal infection Title of the research project Nano scale analysis of lipid molecules of biomembrane topology Recipient (Institution) Akikazu Fujita (Kagoshima University, Joint Faculty of Veterinary Medicine, Professor) Journal article / other material Biochimica Biophysica Acta, 1858, 1298-305 (2016) Title of the paper Nanoscale analysis reveals agonist-sensitive and heterogeneous pools of phosphatidylinositol 4-phosphate in the plasma membrane Title of the research project Positive feed-forward loop of mTOR complex links cellular metabolism to targeted therapy resistance Recipient (Institution) Kenta Masui (Laboratory of Neuropathology, Tokyo Metropolitan Institute of Medical Science, Chief Researcher) Journal article / other material Brain pathology, 25, 755-9 (2015) Title of the paper mTORC2 and metabolic reprogramming in GBM: at the interface of genetics and environment Journal article / other material www.pnas.org/cgi/doi/10.1073/pnas.1511759112 Title of the paper Glucose-dependent acetylation of rictor promotes targeted cancer therapy resistance Title of the research project Analysis of molecular mechanisms for cell fate determination of retinal interneurons Recipient (Institution) Rikako Sanuki (Osaka University, Institute for Protein Research, Assistant Professor) Journal article / other material J Neuroscience, 35, 8004-20 (2015) Title of the paper Prdm13 regulates subtype specification of retinal amacrine interneurons and modulates visual sensitivity Journal article / other material Molecular and Cellular Biology, 35, 2583-96 (2015) Title of the paper Rax homoprotein regulates photoreceptor cell maturation and survival in association with Crx in the postnatal mouse retina Title of the research project Drug discovery for neuropathic pain from processed aconite root Recipient (Institution) Toshiaki Makino (Nagoya City University,Graduate School of Pharmaceutical Sciences, Professor) Journal article / other material Journal of Ethnopharmacoloy, 186, 44-52 (2016) Title of the paper Processed aconite root and its active ingredient neoline may alleviate oxaliplatin-induced peripheral neuropathic pain Title of the research project Development of a comprehensive synthetic strategy and study of biological activity of yuzurimine alkaloids Recipient (Institution) Ichiro Hayakawa (Graduate School of Natural Science and Technology, Okayama University, Associate Professor) Journal article / other material Chem. Commun., 51, 11568-71 (2015) Title of the paper Construction of the [6-7-5-5] tetracyclic core of all the carbocyclic frameworks of yuzurimine-type alkaloids Journal article / other material Org. Biomol. Chem., 13, 9969-76 (2015) Title of the paper Synthesis and structure-activity relationships for cytotoxicity and apoptosis-inducing activity of (+)-halichonine B Title of the research project Development of novel therapy for peripheral artery disease using ApoA-I mimetic peptide Recipient (Institution) Satoshi Imaizumi (Fukuoka University School of Medicine, Assistant Professor) Journal article / other material International Journal of Cardiology, 207, 317-25 (2016) Title of the paper The ApoA-I mimetic peptide FAMP promotes recovery from hindlimb ischemia through a nitric oxide (NO)-related pathway Title of the research project Regulation mechanisms of retroelements by RNA virus Recipient (Institution) Tomoyuki Honda (Institute for Virus Research, Kyoto University, Assistant Professor) Journal article / other material Cell reports, 12, 1948-54 (2015) Title of the paper Transcription profiling demonstrates epigenetic control of non-retroviral RNA virus-derived elements in the human genome Journal article / other material Frontiers in Chemostry, 4, doi:10.3389/fchem.2016.00021 Title of the paper Links between human LINE-1 retrotransposons and hepatitis virus-related hepatocellular carcinoma Journal article / other material Mobile Genetic Elements, 6, Doi: 10.1080/2159256X.2016. 1165785 Title of the paper Endogenous non-retroviral RNA virus elements evidence a novel type of antiviral immunity Journal article / other material Nature Scientific reports, 6, 26154, Doi: 10.1038/srep26154 Title of the paper Long-term expression of miRNA for RNA interface using a novel vector system based on a negative-strand RNA virus Title of the research project Research on the regulation of chronic inflammatory disease by plasmacytoid dendritic cells Recipient (Institution) Hideaki Takagi (Faculty of Medicine, University of Miyazaki, Assistant Professor) Journal article / other material Nature Communications, 7, 11273,Doi:10.1038/nocommons11273 Title of the paper Plasmacytoid dendritic cells orchestrate TLR7-mediated innate and adaptive immunity for the initiation of autoimmune inflammation Title of the research project Genome-wide screening of endocytosis of GPCR Recipient (Institution) Junko Toshima (Faculty of Science And Engineering, Waseda University, Associate Professor) Journal article / other material Biochemical and Biophysical Research Communications, xxx, 1-7 (2016).doi.org/10.1016/j.bbrc.2016.05.099 Title of the paper Lipid droplet proteins, Lds1p, Lds2p and Rrt8p, are implicated in membrane protein transport associated with ergosterol Journal article / other material Journal of Cell Science, 129, 367-79 (2016), doi:10.1242/jcs.176651 Title of the paper Srv2/CAP is required for polarized actin cable assembly and patch internalization during clathrin-mediated endocytosis
- FY2013 Grant Recipients
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Title of the research project CARTS-mediated protein transport from the Golgi complex to the cell surface Recipient (Institution) Yuichi Wakana（Tokyo University of Pharmacy and Life Sciences, School of Life Sciences） Journal article / other material Molecular Biology of the Cell, 26, 4686-4699, (2015) Title of the paper CARTS biogenesis requires VAP-lipid transfer protein complexes functioning at the endoplasmic reticulum-Golgi interface Title of the research project Discovery of New Drug Candidates Based on Development of Site-selective Direct Functionalization of Pyridones Recipient (Institution) Koji Hirano（Department of Applied Chemistry, Graduate School of Engineering, Osaka University） Journal article / other material Angewandte Communications: 53, 10784-10788 (2014) Title of the paper Copper-Mediated C6-Selective Dehydrogenative Heteroarylation of 2-Pyridones with 1,3-Azoles Title of the research project Research on Asymmetric Membrane Elongation Critical for Symmetric Cell Division Recipient (Institution) Tomomi Kiyomitsu (Nagoya University, Graduate School of Science, Assistant Professor) Journal article / other material Trends in Cell Biology, May Vol.25, No.5 286-295 (2015) Title of the paper Mechanisms of daughter cell-size control during cell division Title of the research project ”Memory priming” that determines the start of the critical period for learning Recipient (Institution) Koichi Homma (Teikyo University, Faculty of Pharmaceutical Sciences, Professor) Journal article / other material Communicative & Integrative Biology: Volume7 Issue5 1-4 October 1 , (2014) Title of the paper Expression of the voltage-sensing phosphatase gene in the chick embryonic tissues and in the adult cerebellum Title of the research project Dissecting the mechanism of cellular senescence that regulates tumor microenvironment Recipient (Institution) Shizue Ohsawa (Kyoto University, Graduate School of Biostudies, Associate Professor) Journal article / other material Developmental Biology 395, 19-28(2014) Title of the paper Loss of Rab5 drives non-autonomous cell proliferation through TNF and Ras signaling in Drosophila Journal article / other material Nature Communications DOI:10.1038/ncomms6264 (2014) Title of the paper Mitochondrial defects trigger proliferation of neighbouring cells via a senescence-associated secretory phenotype in Drosophila Title of the research project Development of novel treatment strategies targeting the R-spondin-LGR5 axis of brain tumor stem cells Recipient (Institution) Ryo Nasu (Kyoto Prefectural University of Medicine, Assistant Professor) Journal article / other material BBRC(Biochemical and Biophysical Research Communications), 459, 411-415(2015) Title of the paper Thr160 of Axin1 is critical for the formation and function of the β-catenin destruction complex Title of the research project Elucidating how the auditory information is integrated by morphological techniques Recipient (Institution) Tetsufumi Ito (University of Fukui, Faculty of Medical Sciences, Assistant Professor) Journal article / other material The Journal of Comparative Neurology 00:00-00, (2015) Title of the paper Convergence of Lemniscal and Local Excitatory Inputs on Large GABAergic Tectothalamic Neurons Journal article / other material Brain Research doi.org/10.1016 (2014) Title of the paper Determining auditory-evoked activities from multiple cells in layer 1 of the dorsal cortex of the inferior colliculus of mice by in vivo calcium imaging Title of the research project Membrane type-1 matrix metalloproteinase in multiple myeloma: a novel modulator of the microenvironment Recipient (Institution) Beate Heissig (The University of Tokyo, The Institute of Medical Science, Associate Professor) Journal article / other material Leukemia 29,145-156 (2015) Title of the paper Inhibition of plasmin attenuates murine acute graft-versus-host disease mortality by suppressing the matrix metalloproteinase-9-dependent inflammatory cytokine storm and effector cell trafficking Title of the research project Research on the role of the novel adipocytokine in heart disease Recipient (Institution) Noriyuki Ouchi (Nagoya University, Graduate School of Medicine, Professor) Journal article / other material The FASEB Journal Vol.29 January 141-151 (2015) Title of the paper Adipose-derived protein omentin prevents neointimal formation after arterial injury Journal article / other material Circ Heart Fail DOI:10.1161/114.001647(2015) Title of the paper Neuron-Derived Neurotrophic Factor Ameliorates Adverse Cardiac Remodeling After Experimental Myocardial Infarction Title of the research project The apoptosis-inducing mechanism of biselyngbyaside, a marine macrolide Recipient (Institution) Kiyotake Suenaga (Keio University, Faculty of Science and Technology, Associate Professor) Journal article / other material Organic Letters, 17, 652-655 (2015) Title of the paper Jahanyne, an Apoptosis-Inducing Lipopeptide from the Marine Cyanobacterium Lyngbya sp. Journal article / other material Journal of Natural Products78, 901-908 (2015) Title of the paper Mebamamides A and B, Cyclic Lipopeptides Isolated from the Green Alga Derbesia marina Title of the research project Functional analysis of a novel suppressive factor at fertilization Recipient (Institution) Naofumi Miwa (Toho University, School of Medicine, Associate Professor) Journal article / other material Molecules 20, 9468-9486 (2015) Title of the paper Protein-Carbohydrate Interaction between Sperm and the Egg-Coating Envelope and Its Regulation by Dicalcin, a Xenopus laevis Zona Pellucida Protein-Associated Protein Title of the research project Elucidation of the novel signal network that regulates trafficking of secretory lysosomes Recipient (Institution) Yoshinori Fukui (Kyushu University, Medical Institute of Bioregulation, Professor) Journal article / other material The Journal of Experimental Medici: Vol.211 No.7 1407-14019 (2014) Title of the paper DOCK5 functions as a key signaling adaptor that links FcƐRI signals to microtubule dynamics during mast cell degranulation Title of the research project The Identification of Exosomal Micro RNA Specific for the Recurrence of Hepatocellular Carcinoma Recipient (Institution) Keishi Sugimachi (Kyushu University Beppu Hospital, Associate Professor) Journal article / other material British Journal of Cancer: doi: 10.1038/bjc 2014.621 (2014) Title of the paper Identification of a bona fide microRNA biomarker in serum exosomes that predicts hepatocellular carcinoma recurrence after liver transplantation Title of the research project Development of a novel catalytic asymmetric method for the incorporation of a biologically significant trifluoromethyl group Recipient (Institution) Yoshitaka Hamashima (University of Shizuoka, School of Pharmaceutical Sciences, Professor) Journal article / other material Chemistry European Journal doi:10.1002/chem.201403447 20, 12061-12065 (2014) Title of the paper Dual Catalysis wit Copper and Rhenium for Trifluoromethylation of Propargylic Alcohols: Efficient Synthesis of α-Trifluoromethylated Enones Title of the research project Spatiotemporal analysis of oncogenic signaling by Kit tyrosine kinase ～Mechanism of autonomous proliferation in mastocytosis and gastrointestinal stromal tumor (GIST)～ Recipient (Institution) Yuuki Obata (Tokyo University of Science, Research Institute for Biomedical Sciences, Assistant Professor) Journal article / other material Nature Communications Doi: 10.1038/ncomms6715 Title of the paper Oncogenic Kit signals on endolysosomes and endoplasmic reticulum are essential for neoplastic mast cell proliferation
- FY2012 Grant Recipients
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Title of the research project Molecular mechanism of temperature response through secretory signaling Recipient (Institution) Atsushi Kuhara (Faculty of Science and Engineering, Konan University) Journal article / other material Neurosci Res, 76, 119-24 (2013) Title of the paper Molecular mechanism for trimetric G protein-coupled thermosensation and synaptic regulation in the temperature repsonse circuit of Caenorhabditis elegans Title of the research project Elucidation of the mechanisms by which impaired clearance of apoptotic cells results in severe inflammation Recipient (Institution) Hiroyasu Nakano (Graduate School of Medicine, Juntendo University) Journal article / other material Biochem Biophys Res Commun, 436, 212-6 (2013) Title of the paper Critical contribution of oxidative stress to TNF α-induced necrosis downstream of RIPK1 activation Title of the research project Comprehensive proteomicanalysis of molecules that are targeted for cancer prognosis or therapy Recipient (Institution) Kiyotsugu Yoshida (School of Medicine, Jikei University) Journal article / other material Proc Natl Acad Sci USA , 111, 717-22 (2014) Title of the paper Induction of amphyregulin by p53 promotes apoptosis via control of microRNA biogenesis in response to DNA damage Journal article / other material Cancer Lett, 339, 214-25 (2013) Title of the paper DYRK2 controls the epithelial-mesenchymal transition in breast cancer by degrading Snail Title of the research project Explorative study on lysine demethylase inhibitors by rational drug design Recipient (Institution) Takayoshi Suzuki (Department of Chemistry, Kyoto Prefectural University of Medicine) Journal article / other material J Med Chem, 56, 7222-31 (2013) Title of the paper Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity Journal article / other material Angew Chem Int Ed Engl, 52, 8620-4 (2013) Title of the paper Lysine-specific demethylase 1-selective inactivators: protein-targeted drug delivery mechanism Journal article / other material Comput Struct Biotechnol J, 9, e201402002 (2014) Title of the paper Synthesis, LSD1 inhibitory activity, and LSD1 binding model of optically pure lysine-PCPA conjugates Title of the research project Synthesis of anticancer anthracycline antibiotics having aza-spiro structure Recipient (Institution) Mitsuru Kitamura (Graduate School of Engineering, Kyushu Institute of Technology) Journal article / other material Tetrahedron Lett, 55, 1653-6 (2014) Title of the paper Synthetic study of kosinostatin aglycone: synthesis of BCDE rings using alkoxycarbonylmethylation of diazonaphtoquinone Title of the research project Identification of cytidine deaminase activity for elucidating the molecular mechanism of plant organelle RNA editing Recipient (Institution) Mamoru Sugita (Center for Gene Research, Nagoya University) Journal article / other material Plant Cell Physiol, 54, 1907-16 (2013) Title of the paper Two DYW subclass PPR proteins are involved in RNA editing of ccmFc and atp9 transcripts in the Moss Physcomitrella patens: first completes set of PPR editing factors in plant mitochondria Title of the research project RAC1 inhibitor is an anti-tumor metastasis drug Recipient (Institution) Satoru Yokoyama (Institute of Natural Medicine, Toyama University) Journal article / other material Cancer Sci, 105, 788-94 (2014) Title of the paper RAC1 inhibition as a therapeutic target for gefitinib-resistant non-small-cell lung cancer Title of the research project Molecular mechanism of Derlin family-mediated novel endoplasmic reticulum quality control system Recipient (Institution) Hideki Nishitoh (Department of Medical Sciences, University of Miyazaki) Journal article / other material Genes(Basel), 4, 306-33 (2013) Title of the paper Signaling pathways from the endoplasmic reticulum and their roles in disease Title of the research project Epigenetic regulation by nuclear pore complex in cancer progression. Recipient (Institution) Richard Wong (Institute of Science and Engineering, Kanazawa University) Journal article / other material Cell Cycle, 10, 1456-67 (2011) Title of the paper RNA export factor RAE1 contributes to NUP98-HOXA9-mediated leukemogenesis Title of the research project Elucidation of molecular functions of Imp3 in osteosarcoma progression, and development of novel anti-Imp3 targeted therapeutic approach Recipient (Institution) Takatsune Shimizu (Faculty of Pharmaceutical Sciences, Hoshi University) Journal article / other material Cancer Res, 74, 6531-41 (2014) Title of the paper IGF2 preserves osteosarcoma cell survival by creating an autophagic state of dormancy that protects cells against chemotherapeutic stress Title of the research project Synthetic Studies on the virulent cell wall lipid of Mycobacterium tuberculosis Recipient (Institution) Seijiro Hosokawa (Faculty of Science and Engineering, Waseda University) Journal article / other material Org Lett, 16, 4106-9 (2014) Title of the paper Stereoselective acylation of the E,E-vinylketene Silyl N,O-acetal and its application to the synthesis of khafrefungin Title of the research project Development of an orange-colored bimolecular fluorescence complementation (BiFC) assay Recipient (Institution) Yutaka Kodama (Center for Bioscience Research and Education, Utsunomiya University) Journal article / other material The 12th Japan Prize in Agrecultural Sciences, Achievement Award for Young Scientists (The Foundation of Agrecultural Sciences of Japan) Title of the paper Visualization of protein-protein interactions in living cells Title of the research project Regulation of plasma membrane receptor-like kinase functions by endoplasmic reticulum quality control in plant cells Recipient (Institution) Shuh-ichi Nishikawa（Faculty of Science, Niigata University） Journal article / other material Plant Physiology,182,1979－1990（2020） Title of the paper ERdj3B-Mediated Quality Control Maintains Anther
Development at High Temperatures
- FY2011 Grant Recipients
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Title of the research project Molecular mechanism of self-renewal and proliferation of a hematopoietic cell due to HMGA2 expression Recipient (Institution) Kazuhiko Ikeda (Department of Cardiology and Hematology, Fukushima Medical University) Journal article / other material Clin Lymphoma Myeloma Leuk, 14, e69-72 (2014) Title of the paper Somatic 15q break after long-term stable disease in acute myeloid leukemia Journal article / other material Br J Haematol, 168, 388-49 (2015) Title of the paper Dysregulation of the MIRLET7/HMGA2 axis with methylation of the CDKN2A promoter in myeloproliferative neoplasms Title of the research project The Role of transcription factor Iκβ-ζ in immunity homeostasis Recipient (Institution) Takashi Maruyama (Graduate School of Life Sciences, Tohoku University) Journal article / other material PLoS One, 9, e110838 (2014) Title of the paper The nuclear IκB family protein IκBNS influences the susceptibility to experimental autoimmune encephalomyelitis in a murine model
- FY2007 Grant Recipients
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Title of the research project Analysis of new zebrafish mutants that show the defects in gut epithelium formation. Recipient (Institution) Yutaka Kikuchi (Graduate School of Science, Hiroshima University) Journal article / other material PLoS One, 7, e33675 (2012) Title of the paper DEAD-box protein Ddx46 is required for the development of the digestive organs and brain in zebrafish