Publications

Our former award recipients often notify us of the publication of journal articles and other materials that summarize research that was supported in part by a Foundation grant.

Publications

FY2022 Grant Recipients

Title of the research project	Y Chromosomal Genes Protective against Heart Failure
Recipient (Institution)	Soichi Sano (Osaka Metropolitan University , Department of Cardiology, Graduate School of Medicine)
Journal article / other material	Nature Cardiovascular Research doi.org/10.1038/s44161-024-00441-z
Title of the paper	Disruption of the Uty epigenetic regulator locus in hematopoietic cells phenocopies the profibrotic attributes of Y chromosome loss in heart failure

Title of the research project	Elucidation of Novel Regulatory Mechanism of Glucose Metabolism in Liver Type 2 Innate Lymphocytes by Single Cell Analysis and Spatial Transcriptome Analysis
Recipient (Institution)	Tomoaki Tanaka (Chiba University, Department of Molecular Diagnosis, Professor)
Journal article / other material	Nat Commun . 2022 Sep 15;13(1):5408. doi: 10.1038/s41467-022-33171-6
Title of the paper	Liver group 2 innate lymphoid cells regulate blood glucose levels through IL-13 signaling and suppression of gluconeogenesis
Journal article / other material	Commun Biol. 2023; 6: 787. doi: 10.1038/s42003-023-05160-y
Title of the paper	Identification of genotype–biochemical phenotype correlations associated with fructose 1,6-bisphosphatase deficiency

Title of the research project	Elucidation of the role of alveolar capillary in alveolar formation for clinical application
Recipient (Institution)	Haruko Takano (Nippon Medical School, Department of Molecular Pathophysiology, Institute of Advanced Medical Science)
Journal article / other material	Nature communications doi.org/10.1038/s41467-024-45910-y
Title of the paper	Endothelial cells regulate alveolar morphogenesis by constructing basement membranes acting as a scaffold for myofibroblasts

Title of the research project	Development of three component reaction for site-selective peptide modification
Recipient (Institution)	Kazuya Kanemoto (Tohoku University, Graduate School of Pharmaceutical Sciences)
Journal article / other material	Angew. Chem. Int. Ed. 2024, doi.org/10.1002/anie.202320012
Title of the paper	N-Terminal-Specific Dual Modification of Peptides through Copper-Catalyzed [3+2] Cycloaddition
Journal article / other material	J. Am. Chem. Soc. 2024, 146, 3910.3919 doi.org/10.1021/jacs.3c11524
Title of the paper	Carboiodanation of Arynes: Organoiodine(III) Compounds as Nucleophilic Organometalloids
Journal article / other material	Org. Lett. 2024, 26, 438.443 doi.org/10.1021/acs.orglett.3c03419
Title of the paper	Amination of N.(Organodithio)phthalimides for the Modular Synthesis of Aminodisulfides
Journal article / other material	Chem. Eur. J. 2024, e202400894 doi.org/10.1002/chem.202400894
Title of the paper	Amino- and Alkoxybenziodoxoles: Facile Preparation and Use as Arynophiles
Journal article / other material	Orcid.org/0000-0002-3958-7369 doi.org/10.26434/chemrxiv-2024-1vp1n
Title of the paper	Disulfuration of Azlactones: A Versatile Entry to Unnatural,Disulfide-Linked Amino Acids and Peptides
Journal article / other material	Org. Lett. 2024, 26, 1880.1885 doi.org/10.1021/acs.orglett.4c00184
Title of the paper	Construction of Diverse Pyrrolidine-Based Skeletons through the Ag-Catalyzed Stereoselective Addition.Elimination Reaction of Azomethine Ylides with Nitroallyl Acetates
Journal article / other material	orcid.org/0000-0002-3958-7369 doi.org/10.26434/chemrxiv-2024-1917n
Title of the paper	Precision Synthesis of Chimeric Peptides through Site-Specific Azomethine Ylide.Dehydroalanine Cycloaddition

Title of the research project	Molecular basis of calcium ion-regulated cellular uptake of nutrients into cancer cells
Recipient (Institution)	Hisaaki Hirose (Kyoto University, Institute for Chemical Research)
Journal article / other material	Genes Cells. 2024 doi: 10.1111/gtc.13118
Title of the paper	ATP2B4 is an essential gene for epidermal growth factor-induced macropinocytosis in A431 cells

Title of the research project	Defective mitophagy in pancreatic beta-cells leads to diabetes
Recipient (Institution)	Kyota Aoyagi (Kyorin University School of Medicine, Department of Cellular Biochemistry)
Journal article / other material	nature.com/scientificreports/ doi.org/10.1038/s41598-024-56769-w
Title of the paper	Imeglimin mitigates mitochondria to restore insulin secretion and suppress apoptosis of pancreatic β.cells from db/db mice

Title of the research project	Interorgan networks of islets with liver, fat, or macrophages to regulate β-cell mass
Recipient (Institution)	Jun Shirakawa (Gunma University, Institute for Molecular and Cellular Regulation (IMCR) )
Journal article / other material	Endocrinology, 2023, 164, 1.13 doi.org/10.1210/endocr/bqad095
Title of the paper	Protective Effects of Imeglimin and Metformin Combination Therapy on β-Cells in db/db Male Mice

Title of the research project	The mechanism of early placental development regulated by a virus-derived gene
Recipient (Institution)	Hirosuke Shiura (University of Yamanashi, Graduate Faculty of Interdisciplinary Research)
Journal article / other material	Frontiers in Cell and Developmental Biology 01 frontiersin.org doi 10.3389/fcell.2023.1273638
Title of the paper	Roles of retrovirus-derived PEG10 and PEG11/RTL1 in mammalian development and evolution and their involvement in human disease

Title of the research project	Elucidation of the disease development caused by disruption of a novel phospholipid transport factor required for mitochondrial homeostasis
Recipient (Institution)	Yasuhiro Horibata (Dokkyo Medical University School of Medicine, Department of Biochemistry)
Journal article / other material	Archives of Biochemistry and Biophysics 752 (2024) 109871 doi.org/10.1016/j.abb.2023.109871
Title of the paper	Archives of Biochemistry and Biophysics

FY2021 Grant Recipients

Title of the research project	Molecular mechanism of lysosomal damage repair by TFEB
Recipient (Institution)	Shuhei Nakamura（Graduate School of Frontier Biosciences, Osaka University）
Journal article / other material	PLOS Genetics doi.org/10.1371/journal.pgen.1010264
Title of the paper	PACSIN1 is indispensable for amphisomelysosome fusion during basal autophagy and subsets of selective autophagy
Journal article / other material	Proceedings of the National Academy of Sciences of the United States of America 121(2) e2306454120 2024 doi.org/10.1073/pnas.2306454120
Title of the paper	HKDC1, a target of TFEB, is essential to maintain both mitochondrial and lysosomal homeostasis, preventing cellular senescence
Journal article / other material	EMBO Rep. 2023 Dec 6;24(12):e57300. doi:10.15252/embr.202357300
Title of the paper	Microautophagy regulated by STK38 and GABARAPs is essential to repair lysosomes and prevent aging.
Journal article / other material	Proc Natl Acad Sci U S A . 2023 Sep 26;120(39):e2221553120. doi: 10.1073/pnas.2221553120. Epub 2023 Sep 18.
Title of the paper	Neuronal MML-1/MXL-2 regulates systemic aging via glutamate transporter and cell nonautonomous autophagic and peroxidase activity.

Title of the research project	Investigation of cellular dynamics of CD73-expressing mesenchymal stem cells in the bone marrow microenvironment
Recipient (Institution)	Kenichi Kimura (Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance, University of Tsukuba)
Journal article / other material	biorxiv, May 7th 2024, doi.org/10.1101/2024.05.02.592287
Title of the paper	A novel genetic mouse model of fatal aortic dissection reveals massive inflammatory cell infiltration in the thoracic aorta

Title of the research project	Structural and functional analysis of primary cation transporters and elucidation of the substrate specificity by gain-of-function mutant
Recipient (Institution)	Kazuhiro Abe（Graduate school of Pharmaceutical Sciences, Nagoya University, Associate Proffessor）
Journal article / other material	Nature communications 09 Sept. 2022 doi.org/10.1038/s41467-022-32793-0
Title of the paper	Structure and function of H+/K+ pump mutants reveal Na+/K+ pump mechanisms
Journal article / other material	Communications Biology, 2023, 6, 956, doi.org/10.1038/s42003-023-05334-8
Title of the paper	Deep learning driven de novo drug design based on gastric proton pump structures
Journal article / other material	Biochim Biophys Acta Mol Cell Res, 2023, 1870, 119543, doi.org/10.1016/j.bbamcr.2023.119543
Title of the paper	An unusual conformation from Na+-sensitive non-gastric proton pump mutants reveals molecular mechanisms of cooperative Na+-binding

Title of the research project	Hematopoietic stem cell aging and mitochondria aging
Recipient (Institution)	Takayoshi Matsumura（Division of Inflammation Research, Center for Molecular Medicine. Division of Cardiovascular Medicine., Jichi Medical University）
Journal article / other material	Nature Communications \| ( 2022) 13:7064 doi.org/10.1038/s41467-022-34906-1
Title of the paper	A Myb enhancer-guided analysis of basophil and mast cell differentiation

Title of the research project	Significance and spatial profiling of phospholipid metabolism in NASH
Recipient (Institution)	Hayato Nakagawa（Department of Gastroenterology and Hepatology, Mie University）
Journal article / other material	J Clin Invest. 2022;132(11):e151895. doi.org/10.1172/JCI151895.
Title of the paper	Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatohepatitis

Title of the research project	Cryo-electron microscopy studies for disease pathogenesis of Xeroderma Pigmentosum
Recipient (Institution)	Syota Matsumoto（Institute for Quantitative Biosciences, The university of Tokyo）
Journal article / other material	Cancer Science.23-May-2023, doi.org/10.1111/cas.15850
Title of the paper	Chromatin structure related to oncogenesis

Title of the research project	Analysis of brain aging caused by the disruption of "nuclear-axon crosstalk" machinery
Recipient (Institution)	Kenichiro Kuwako（School of Medicine, Department of Neural and Muscular Physiology , Shimane University, Associate Professor）
Journal article / other material	Development (2022) 149, dev201214. doi:10.1242/dev.201214
Title of the paper	N-WASP-Arp2/3 signaling controls multiple steps of dendrite maturation in Purkinje cells in vivo

Title of the research project	Development of asymmetric synthesis of sulfoximine analogs as bioisosteres
Recipient (Institution)	Taichi Kano (Graduate School of Engineering, Tokyo University of Agriculture and Technology)
Journal article / other material	Organic Letters, 2023, 25, 6677-6681 doi.org/10.1021/acs.orglett.3c02534
Title of the paper	Transsulfinamidation of Sulfinamides with Amines

Title of the research project	Achieve a comprehensive understanding of the pathogenesis of type 1 diabetes mellitus, leading to development of the prevention measures
Recipient (Institution)	Keiichiro Mine (Division of Metabolism and Endocrinology, Department of Internal Medicine, Faculty of Medicine, Saga University)
Journal article / other material	Nature Communications \| ( 2024) 15:1337 doi.org/10.1038/s41467-024-45573-9
Title of the paper	TYK2 signaling promotes the development of autoreactive CD8+ cytotoxic T lymphocytes and type 1 diabetes

Title of the research project	Potential implications of enzymatic activity of the multifunctional protease NRDC as a new therapeutic target for cardiovascular disease
Recipient (Institution)	Mikiko Ohno (Department of Pharmacology, Shiga University of Medical Science)
Journal article / other material	Internal and Emergency Medicine 6 December 2023 doi.org/10.1007/s11739-023-03508-0
Title of the paper	Auxiliary roles of nardilysin in the early diagnosis of acute coronary syndrome: a prospective cohort study, the Nardi.ACS study
Journal article / other material	Biochemical and Biophysical Research Communications 15 April 2024 doi.org/10.1016/j.bbrc.2024.149961
Title of the paper	Nardilysin in vascular smooth muscle cells controls blood pressure via the regulation of calcium dynamics

Title of the research project	Elucidating the mechanism of skin stem cell aging by targeting anti-aging matrix Fibulin-7
Recipient (Institution)	Aiko Sada (International Research Center for Medical Sciences (IRCMS), Kumamoto University)
Journal article / other material	EMBO Rep . 2022 Dec 6;23(12):e55478. doi: 10.15252/embr.202255478. Epub 2022 Oct 24.
Title of the paper	The extracellular matrix fibulin 7 maintains epidermal stem cell heterogeneity during skin aging

Title of the research project	Studies of genetic basis of early onset cardiac conduction system disease and disease mechanism-based personalized medicine
Recipient (Institution)	Kenshi Hayashi（School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University）
Journal article / other material	Journal of Molecular and Cellular Cardiology doi.org/10.1016/j.yjmcc.2023.03.001
Title of the paper	The utility of zebrafish cardiac arrhythmia model to predict the pathogenicity of KCNQ1 variants

Title of the research project	Analysis of the mechanism underlying extracellular release of tau for treatment of Alzheimer’s disease
Recipient (Institution)	Shigeki Arawaka (Department of Internal Medicine IV, Division of Neurology, Faculty of Medicine, Osaka Medical and Pharmaceutical University)
Journal article / other material	Biochemical and Biophysical Research Communications 725 (2024) 150267 doi.org/10.1016/j.bbrc.2024.150267
Title of the paper	Biochemical and Biophysical Research Communications

Title of the research project	Study of functional deficits of microglia and accelerated onset of neurodegenerative disorders
Recipient (Institution)	Keiro Shirotani（The Laboratory of Genome-based Drug Discovery, Nagasaki University）
Journal article / other material	J. Biochem 2022;00(00):1-7 doi.org/10.1093/jb/mvac073
Title of the paper	The role of TREM2 N-glycans in trafficking to the cell surface and signal transduction of TREM2

Title of the research project	Analysis of ncRNA transcription mediated chromatin modulation mechanism
Recipient (Institution)	Kouji Hirota (Department of Chemistry, Graduate School of Science, Metropolitan University)
Journal article / other material	PLoS One. 2024;19(1):e0294191. Epub 2024/01/22. doi: 10.1371/journal.pone.0294191.
Title of the paper	Metabolic stress-induced long ncRNA transcription governs the formation of meiotic DNA breaks in the fission yeast fbp1 gene
Journal article / other material	Nat Struct Mol Biol. 2023;30(9):1286-94. Epub 2023/08/18. doi: 10.1038/s41594-023-01064-x. PubMed PMID: 37592094; PubMed Central PMCID: PMCPMC10497406.
Title of the paper	PCNA recruits cohesin loader Scc2 to ensure sister chromatid cohesion.
Journal article / other material	DNA Repair (Amst). 2023;127:103503. Epub 2023/04/27. doi: 10.1016/j.dnarep.2023.103503. PubMed PMID: 37099849.
Title of the paper	CTF18-RFC contributes to cellular tolerance against chain-terminating nucleoside analogs (CTNAs) in cooperation with proofreading exonuclease activity of DNA polymerase ε.

Title of the research project	Intrinsic barrier dysfunction in multiple sclerosis patient
Recipient (Institution)	Hideaki Nishihara（Department of Neurotherapeutics, Yamaguchi University）
Journal article / other material	Adv. Healthcare Mater. 2022, 11, 2200804 doi: 10.1002/adhm.202200804
Title of the paper	The Modular μSiM: A Mass Produced, Rapidly Assembled,and Reconfigurable Platform for the Study of Barrier Tissue Models In Vitro
Journal article / other material	Journal of Visualized Experiments 2023 Issue 195, doi: 10.3791/65134
Title of the paper	Differentiation of Human Induced Pluripotent Stem Cells to Brain Microvascular Endothelial Cell-Like Cells with a Mature Immune Phenotype.

Title of the research project	Development of an innovative diagnostic and therapeutic method that combines radionuclide therapy and novel boron neutron capture therapy
Recipient (Institution)	Kazuma Ogawa (Institute for Frontier Science Initiative, Kanazawa University)
Journal article / other material	J Med Chem. 65(24) 16741-16753 (2022) doi.org/10.1021/acs.jmedchem.2c01586
Title of the paper	An RGD peptide conjugated dodecaborate with Ga-DOTA complex: a preliminary study for the development of theranostic agents for boron neutron capture therapy and its companion diagnostics.

Title of the research project	Molecular mechanism of neuroprotection after ischemic stroke
Recipient (Institution)	Hiroo Takahashi（Department of Molecular Neurobiology, Kagawa University）
Journal article / other material	Neuroscience Research 186 (2023) 3.9 doi: 10.1016/j.neures.2022.10.005. Epub 2022
Title of the paper	Molecular mechanisms underlying activity-dependent ischemic tolerance in the brain

Title of the research project	Molecular mechanism for the mutual relationship between macrophage chemotaxis and activation
Recipient (Institution)	Etsuko Toda（Department of Analytic Human Pathology, Nippon Medical School）
Journal article / other material	Kidney Int.2022 Dec. doi.org/10.1016/j.kint.2022.07.031
Title of the paper	nhibition of the chemokine signal regulator FROUNT by disulfiram ameliorates crescentic glomerulonephritis

Title of the research project	Catalytic Asymmetric Indole Halocyclization for Construction of Bioactive Structures
Recipient (Institution)	Keisuke Asano（Institute for Catalysis, Hokkaido University）
Journal article / other material	Chem. Rec. 2022, e202200200 doi.org/10.1002/tcr.202200200 tcr.wiley-vch.de
Title of the paper	Organocatalytic Access to Tetrasubstituted Chiral Carbons Integrating Functional Groups
Journal article / other material	Chemistry — A European Journal, 2024, 30, e202303399.doi: 10.1002/chem.202303399
Title of the paper	trans-Cyclooctenes as Scavengers of Bromine Involved in Catalytic Bromination

Title of the research project	Analysis of structures and functions of plant nuclear actin microfilaments
Recipient (Institution)	Noriko Inada (Graduate School of Life and Environmental Sciences, Osaka Prefecture University)
Journal article / other material	Plant&Cell Physiology, 2023, 64(10), 1231-1242, doi:10.1093/pcp/pcad092
Title of the paper	Organocatalytic Access to Tetrasubstituted Chiral Carbons Integrating Functional Groups

FY2020 Grant Recipients

Title of the research project	Targeting Spliceosomal Mutant Leukemias by a Novel ASO Therapy
Recipient (Institution)	Akihide Yoshimi（Cancer RNA Research Unit, National Cancer Center Research Institute）
Journal article / other material	Cancer Sci, 2022 Feb;113(2):373-381. doi: 10.1111
Title of the paper	Aberrant RNA splicing and therapeutic opportunities in cancers

Title of the research project	Molecular basis for early dendritic cell lineage specification during pathogen infection
Recipient (Institution)	Daisuke Kurotaki（International Research Center for Medical Sciences, Kumamoto University）
Journal article / other material	PNS August 15, 2022 doi.org/10.1073/pnas.2207009119
Title of the paper	Chromatin structure undergoes global and local reorganization during murine dendritic cell development and activation

Title of the research project	Elucidation of the mechanisms of new tubulointerstitial nephritis with IgM-positive plasma cells and comprehensive analysis of IgM-type autoantibodies in the serum
Recipient (Institution)	Naoki Takahashi（Department of Nephrology, University of Fukui）
Journal article / other material	CEN Case Reports, 2023,12,32-38 doi.org/10.1007/s13730-022-00715-0
Title of the paper	Fanconi syndrome in an elderly patient with membranous nephropathy during treatment with the immunosuppressant mizoribine

Title of the research project	Synthesis and development of flavan-derived polyphenol with protective effect against amyloid-beta-induced toxicity
Recipient (Institution)	Ken Ohmori（Department of Chemistry, School of Science, Tokyo Institute of Technology）
Journal article / other material	Angewandte Chemie, International Edition, 2022, 61, e202205106. doi.org/10.1002/anie.202205106
Title of the paper	Total Synthesis of Parameritannin A2, a Branched Epicatechin Tetramer with Two Double Linkages
Journal article / other material	Organic and Biomolecular Chemistry, 2022, 20, 7419-7423. doi.org/10.1039/D2OB01416E
Title of the paper	De novo synthesis od dimerization-ready flavan unit via intramolecular Pummerer/Friedel-Crafts cascade

Title of the research project	Molecular genetic analysis of plant sub-stomatal chamber development
Recipient (Institution)	Yuki Yoshida（Faculty of Advanced Science and Technology, Kumamoto University）
Journal article / other material	Microbiol Spectr. 2021 Sep 3;9(1):e0051121. doi: 10.1128/Spectrum.00511-21.
Title of the paper	Entamoeba Chitinase is Required for Mature Round Cyst Formation

Title of the research project	Highly Efficient Synthesis of Rare Macrolides, Directing Drug Discovery
Recipient (Institution)	Jun Ishihara (School of pharmaceutical sciences, Pharmaceutical organic chemistry department, Nagasaki University)
Journal article / other material	Molecules 2024, 29(5), 1187 doi.org/10.3390/molecules29051187
Title of the paper	Progress in Lewis-Acid-Templated Diels–Alder Reactions

Title of the research project	Catalytic Enantioselective α-Halogenation of Acylpyrazoles Directed towards Synthesis of Chiral Drugs
Recipient (Institution)	Kazuaki Ishihara（Graduate School of Engineering, Nagoya University）
Journal article / other material	Synlett 2022, 33, 585-588, DOI: 10.1055/a-1750-8481; Art ID: st-2021-v0465-l
Title of the paper	Thorpe-Ingold Effect on High-Performance Chiral -Copper(II) Catalyst
Journal article / other material	ACS Catal. 2022, 12, 1012-1017 doi.org/10.1021/acscatal.1c05500
Title of the paper	A π-Cu(II)-π Complex as an Extremely Active Catalyst for Enantioselective α-Halogenation of N-Acyl-3,5-dimethylpyrazoles
Journal article / other material	Journal of the American Chemical Society 2023, 145, 27080-27088 doi.org/10.1021/jacs.3c10820
Title of the paper	Tande　m Isomerization/α,β-Site-Selective and Enantioselective　Addition Reactions of N‑(3-Butynoyl)-3,5-dimethylpyrazole Induced by Chiral π−Cu(II) Catalysts

Title of the research project	Research on infertility
Recipient (Institution)	Keiichiro Ishiguro（Institute of Molecular Embryology and Genetics, Kumamoto University）
Journal article / other material	NATURE COMMUNICATIONS 2021 doi.org/10.1038/s41467-021-23378-4
Title of the paper	Meiosis-speciﬁc ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis
Journal article / other material	J-STAGE Advance published date: 25 December 2021 doi.org/10.1266/ggs.21-00054
Title of the paper	MEIOSIN directs initiation of meiosis and subsequent meiotic prophase program during spermatogenesis
Journal article / other material	iScience 25, 104008, April 15, 2022 ^a 2022 The Author(s). doi.org/10.1016/j.isci.2022.104008
Title of the paper	FBXO47 is essential for preventing the synaptonemal complex from premature disassembly in mouse male meiosis
Journal article / other material	Sexual Development DOI: 10.1159/000520682
Title of the paper	Sexually Dimorphic Properties in Meiotic Chromosome
Journal article / other material	Current Topics in Developmental Biology 151, 1-26 (2023) DOI: 10.1016/bs.ctdb.2022.04.0
Title of the paper	Mechanism of initiation of meiosis in mouse germ cells
Journal article / other material	iScience 25 (4), 104008 (2022) doi.org/10.1016/ j.isci.2022.104008
Title of the paper	FBXO47 is essential for preventing the synaptonemal complex from premature disassembly in mouse male meiosis
Journal article / other material	Sexual Development 1-11 (2022) doi:10.1159/000520682
Title of the paper	Sexually dimorphic properties in meiotic chromosome

Title of the research project	A chemical genetics approach to identify direct substrates of Alzheimer’s disease-associated kinase MARK4 in neurons
Recipient (Institution)	Kanae Ando (Graduate school of science, Department of Biological Sciences, Tokyo Metropolitan University)
Journal article / other material	Brain Commun. 2024 Apr 17;6(3):fcae136. doi: 10.1093/braincomms/fcae136. PMID: 38712317
Title of the paper	Mark4 ablation attenuates pathological phenotypes in a mouse model of tauopathy
Journal article / other material	Genes Cells. 2024 Apr;29(4):337-346. doi: 10.1111/gtc.13101.
Title of the paper	Microtubule-affinity regulating kinase family members distinctively affect tau phosphorylation and promote its toxicity in a Drosophila model
Journal article / other material	Neurobiol Dis. 2023 Nov;188:106334. doi: 10.1016/j.nbd.2023.106334.
Title of the paper	A cell-penetrating peptide derived from SARS-CoV-2 protein Orf9b allosterically inhibits MARK4 activity and mitigates tau toxicity
Journal article / other material	eLife, https://doi.org/10.7554/eLife.95576.1
Title of the paper	Axonal distribution of mitochondria maintains neuronal autophagy during aging via eIF2β

Title of the research project	Glial control of behavioral disorders induced by social distancing
Recipient (Institution)	Ko Matsui (Graduate School of Life Sciences, Super-network Brain Physiology, Tohoku University)
Journal article / other material	eLife (2024) , 13: RP93721. doi.org/10.7554/eLife.93721.3
Title of the paper	Plastic vasomotion entrainment
Journal article / other material	Neuroscience Research (2023), 202: 39-51. doi.org/10.1016/j.neures.2023.11.008
Title of the paper	Glial tone of aggression
Journal article / other material	Glia(2023) , 71: 2401-2417. doi.org/10.1002/glia.24431
Title of the paper	Glial modulation of the parallel memory formation
Journal article / other material	Brain(2023), 146: 576-586. doi.org/10.1093/brain/awac355
Title of the paper	Local brain environment changes associated with epileptogenesis
Journal article / other material	Nature Neuroscience(2022) , 25, 1458-1469. doi.org/10.1038/s41593-022-01184-5
Title of the paper	Glial modulation of the parallel memory formation

Title of the research project	Genome wide analysis of DNA methylation and transcription dynamics in ICF syndrome
Recipient (Institution)	William Addison（Division of Molecular Signaling and Biochemistry, Kyushu Dental University）
Journal article / other material	FASEB J. 2022;36:e22153. doi.org/10.1096/fj.202101402R
Title of the paper	Inhibition of TET- mediated DNA demethylation suppresses osteoblast differentiation

Title of the research project	Exploration of pharmaceutical resources based on rapid synthesis and machine learning analysis of optically active compounds
Recipient (Institution)	Shinobu Takizawa（The Institute of Scientific and Industrial Research, Osaka University）
Journal article / other material	Organic & Biomolecular Chemistry, 2022, 20, 65586561, doi: 10.1039/d2ob00940d
Title of the paper	DAST-mediated ring-opening of cyclopropyl silyl ethers in nitriles: facile synthesis of allylic amides via a Ritter-type process
Journal article / other material	Chemical Communications, 2023, 59, 9956, doi: 10.1039/d3cc02719h
Title of the paper	Light-controlled pKa value of chiral Brønsted acid catalysts in enantioselective aza-Friedel–Crafts reaction

Title of the research project	Development of Protein Ligand Library for Stereodivergent Synthesis
Recipient (Institution)	Nobutaka Fujieda（Graduate School of Life and Environmental Sciences, Biophysical Chemistry, Osaka Prefecture University）
Journal article / other material	Chem. Sci., 14, 3932-3937 (2023). doi.org/10.1039/D2SC06809E
Title of the paper	An Artificial Metallolyase with Pliable 2-His-1-Carboxylate Facial Triad for Stereoselective Michael Addition

Title of the research project	Development of novel GVHD mechanism and therapy targeting metabolic disturbance of intestinal epithelial cells that leads to dysbiosis.
Recipient (Institution)	Hideaki Fujiwara（Department of Hematology and Oncology, Okayama University Hospital）
Journal article / other material	NATuRe IMMuNOLOgY VOL 22 NOV.2021 doi.org/10.1038/s41590-021-01048-3
Title of the paper	Mitochondrial complex II in intestinal epithelial cells regulates T cell-mediated immunopathology
Journal article / other material	Frontiers in Immunolog August 2021, Volume 12 Article 703298 doi: 10.3389/fimmu.2021.703298
Title of the paper	Crosstalk Between Intestinal Microbiota Derived Metabolites and Tissues in Allogeneic Hematopoietic Cell Transplantation

Title of the research project	Development of supramolecular hydrogel that enable drug delivery into central nervous system
Recipient (Institution)	Shinya Kimura（Development of pharmaceutical chemistry, Meiji Pharmaceutical University）
Journal article / other material	Chem Asian J. 2021, 16, 1937 - 1941 doi.org/10.1002/asia.202100376
Title of the paper	Enzymatic Hydrolysis-Responsive Supramolecular Hydrogels Composed of Maltose-Coupled Amphiphilic Ureas
Journal article / other material	Chem Asian J. 2021, 16, 1750 - 1755 doi.org/10.1002/asia.202100433
Title of the paper	Effect of Alkyl Chain Length of N-Alkyl-N’-(2-benzylphenyl)ureas on Gelation
Journal article / other material	Chem. Pharm. Bull. 69, 1131-1135 (2021) doi.org/10.1248/cpb.c21-00539
Title of the paper	Formation of pH-Responsive Supramolecular Hydrogels in Basic Buffers:Self-assembly of Amphiphilic Tris-Urea
Journal article / other material	Chem. Pharm. Bull. 70, 443-447 (2022) doi.org/10.1248/cpb.c22-00134
Title of the paper	Multiple Stimuli-Responsive Supramolecular Gel Formed from Modified Adenosine
Journal article / other material	Asian Journal of Organic Chemistry、2022、11、e202200534. doi.org/10.1002/ajoc.202200534
Title of the paper	Simple Strategy for Benzo[de]chromene-7,8-dione Synthesis via Tandem Sonogashira Coupling and Intramolecular Cyclization Reactions
Journal article / other material	Chemical and Pharmaceutical Bulletin、2023、71、229-233. doi.org/10.1248/cpb.c22-00758
Title of the paper	Bovine Serum Albumin Hydrogel Formation: pH Dependence and Rheological Analyses
Journal article / other material	The Journal of Organic Chemistry、2023、88、8714–8721. doi.org/10.1021/acs.joc.3c00598
Title of the paper	Simple Strategy for Benzo[g]chromene Synthesis via a Photochemical Intramolecular Cyclization Reaction

Title of the research project	Understanding of the molecular mechanisms that regulate production of neuronal diversity
Recipient (Institution)	Takumi Suzuki（laboratory of developmental biology, Ibaraki University, Assistant Professor）
Journal article / other material	Fly, 2022, 16, 222-232, doi.org/10.1080/19336934.2022.2073158
Title of the paper	Cutting edge technologies expose the temporal regulation of neurogenesis in the Drosophila nervous system

Title of the research project	Identification of the molecular mechanisms in the microbes enhanced oogenesis
Recipient (Institution)	Ritsuko Suyama ( Graduate School of Frontier Biosciences, Osaka university )
Journal article / other material	Communications biology 2023, 6:1287 doi.org/10.1038/s42003-023-05660-x
Title of the paper	Microbes control Drosophila germline stem cell increase and egg maturation through hormonal pathways

Title of the research project	Investigation of hepatic metabolic homeostasis and its deterioration by physiological and bioinformatic analyses of vagus nerve-mediated organ-crosstalk
Recipient (Institution)	Hiroshi Inoue（Metabolism and Nutrition Research Unit, Institute for Frontier Science Initiative, Kanazawa University, Professor）
Journal article / other material	Nat Commun. 2023 Jan 23;14(1):167. doi.org/10.1038/s41467-023-35804-w
Title of the paper	The transcription factor ATF3 switches cell death from apoptosis to necroptosis in hepatic steatosis in male mice.

FY2019 Grant Recipients

Title of the research project	Evolution of membrane morphogenesis in Asgard archaea
Recipient (Institution)	Yosuke Senju（Research Institute for Interdisciplinary Science (RIIS),Okayama University）
Journal article / other material	Springer Science+Business Media, LLC, part of Springer Nature 2021 doi.org/10.1007/978-1-0716-1142-5_14,
Title of the paper	Liposome Co-sedimentation and Co-flotation Assays to Study Lipid-Protein Interactions

Title of the research project	Effects of carbon beam irradiation on connexin and sympathetic nerve expressions and antiarrhythmic effect in rabbits with atrial
Recipient (Institution)	Mari Amino（Department of Cardiovascular Medicine,Tokai University,Assistant Professor）
Journal article / other material	Circulation Journal doi: 10.1253/circj.CJ-22-0527
Title of the paper	Heavy Ion Irradiation Reduces Vulnerability to Atrial Tachyarrhythmias ― Gap Junction and Sympathetic Neural Remodeling ―

Title of the research project	Identification of premalignant gastric glands in chronic gastritis mucosa and prophylactics for gastric cancer development.
Recipient (Institution)	Takahiro Shimizu（Endoscopy Unit,Kyoto University Hospital）
Journal article / other material	Cancer Research, 2022, 82(9), 1712-1723, doi: 10.1158/0008-5472.CAN-21-1523
Title of the paper	Expansion of Gastric Intestinal Metaplasia with Copy Number Aberrations Contributes to Field Cancerization

Title of the research project	Mechanism of inflammatory memory in hematopoietic stem cell using informatics unifying multidimensional single cell data
Recipient (Institution)	Hitoshi Takizawa（International Research Center for Medical Sciences (IRCMS),Kumamoto University,Professor）
Journal article / other material	Front Immunol 2020 Nov 24. doi: 10.3389/fimmu.2020.585367
Title of the paper	Immuno-Modulation of Hematopoietic Stem and Progenitor Cells in Inflammation

Title of the research project	Molecular mechanisms of mycobacterial effector protein for the development of novel anti-TB drugs
Recipient (Institution)	Giichi Takaesu（Molecular Microbiology Group, Tropical Biosphere Research Center, University of the Ryukyus）
Journal article / other material	FASEB Journal, 2022, Volume 36, Issue 1, e22096, doi: 10.1096/fj.202101074RR
Title of the paper	GRIM-19 is a target of mycobacterial Zn(2+) metalloprotease 1 and indispensable for NLRP3 inflammasome activation

Title of the research project	Functional mechanisms and dynamics of oxytocin in autism spectrum disorder
Recipient (Institution)	Teruhiro Okuyama（Institute for Quantitative Biosciences (IQB),The University of Tokyo）
Journal article / other material	bioRxiv June 25, 2021 doi.org/10.1101/2021.06.25.449869;
Title of the paper	Disrupted social memory ensembles in the ventral hippocampus underlie social amnesia in autism-associated Shank3 mutant mice
Journal article / other material	Current Opinion in Neurobiolog, June 2021 doi.org/10.1016/j.conb.2020.12.008
Title of the paper	Distinct functions of ventral CA1 and dorsal CA2 in social memory
Journal article / other material	Development, Growth & Differentiation, December 2020 DOI: 10.1111/dgd.12697
Title of the paper	Diverse sensory cues for individual recognition
Journal article / other material	Molecular Psychiatry, in press
Title of the paper	Disrupted social memory ensembles in the ventral hippocampus underlie social amnesia in autism-associated Shank3 mutant mice

Title of the research project	Fasting Specific Metabolic Regulation by the Circadian Clock
Recipient (Institution)	Kenichiro Kiuchi（School of Medicine,Keio University,）
Journal article / other material	Mol Aspects Med. 2021 Aug;80:100984. doi: 10.1016/j.mam.2021.100984. Epub 2021 Jun 20.
Title of the paper	Circadian rhythms in the tissue-specificity from metabolism to immunity: insights from omics studies

Title of the research project	Cell senescence effects on transcriptional regulation and differentiation in beige preadipocytes
Recipient (Institution)	Kenji Ikeda（Department of Molecular　Endocrinology and Metabolism,Tokyo Medical and Dental University）
Journal article / other material	Front Endocrinol (Lausanne). 2020 Jul 28; 11: 498 doi: 10.3389/fendo.2020.00498
Title of the paper	UCP1 Dependent and Independent thermogenesis in Brown and Beige Adipocytes

Title of the research project	Development of Planar Chiral Cyclic (Amino)(ferrocenyl)carbene Ligands for Medicinal Chemistry
Recipient (Institution)	Kazuhiro Yoshida（Department of Chemistry, Graduate School of Science, Chiba University）
Journal article / other material	Adv. Synth. Catal. 2021, 363, 1662-1671 doi :10.1002/adsc.202001419
Title of the paper	Enantioselective Desymmetrization of 1,3‐Disubstituted Adamantane Derivatives via Rhodium‐Catalyzed C-H Bond Amination: Access to Optically Active Amino Acids Containing Adamantane Core
Journal article / other material	J. Org. Chem. 2022, 87, 3007-3013 doi :10.1021/acs.joc.1c02836
Title of the paper	Chiral Bicyclic NHC/Rh Complexes and Their Application to Catalytic Asymmetric Ring-Opening Reaction of Oxabenzonorbornadienes with Amines

Title of the research project	Molecular mechanism underlying development of memory-like Group 2 innate lymphoid cells
Recipient (Institution)	Takashi Ebihara（Department of Medical Biology,Akita University Graduate School of Medicine）
Journal article / other material	Cells 2020, 9, 1193; doi:10.3390/cells9051193
Title of the paper	Dichotomous Regulation of Acquired Immunity by Innate Lymphoid Cells
Journal article / other material	Allergology International 70 (2) 2021, 174-180 doi.org/10.1016/j.alit.2020.11.007
Title of the paper	Trained innate lymphoid cells in allergic diseases
Journal article / other material	J Exp Med (2023) 220 (7): e20222005. doi.org/10.1084/jem.20222005
Title of the paper	TIGIT mediates activation-induced cell death of ILC2s during chronic airway allergy

Title of the research project	Development of urolithiasis therapy by immune response and repair mechanism
Recipient (Institution)	Takahiro Yasui（Graduate School of Medicine, Nagoya City University）
Journal article / other material	Front Immunol. 2021 May 24;12:673690. doi: 10.3389/fimmu.2021.673690. eCollection 2021
Title of the paper	Macrophage Function in Calcium Oxalate Kidney Stone Formation: A Systematic Review of Literature

Title of the research project	The model chicken of cardiac septum defect； A new tool for analysis of structural heart disease
Recipient (Institution)	Saori Matsuhana（Department of Biology, Graduate School of Science, Kobe University）
Journal article / other material	Cells & Development、2021、167、 203725-203725、 doi :10.1016/j.cdev.2021.203725
Title of the paper	Identification of regulatory elements for MafB expression in the cardiac neural crest
Journal article / other material	Developmental Biology、2023、495、1-7 doi:10.1016/j.ydbio.2022.12.006
Title of the paper	The cardiac neural crest gene MafB ectopically directs CXCR4 expression in the trunk neural crest

Title of the research project	In vivo Imaging of Brain in CNS Lupus Defines Unique Roles for Chemoattractants
Recipient (Institution)	Yoshishige Miyabe（Institute for Advanced Medical Sciences,Nippon Medical School）
Journal article / other material	JMA J. 2020;3(3): DOI: 10.31662/jmaj.2020-0019
Title of the paper	Targeting the Chemokine System in Rheumatoid Arthritis and Vasculitis

Title of the research project	Elucidating the system to generate dormancy that confer chemotherapy-resistance to cancer cells
Recipient (Institution)	Keisuke Nimura（Division of Gene Therapy Science,Osaka University,Associate Professor）
Journal article / other material	Cancers 2022, 14, 3580 doi: 10.3390/cancers14153580.
Title of the paper	Identification of Malignant Cell Populations Associated with Poor Prognosis in High-Grade Serous Ovarian Cancer Using Single-Cell RNA Sequencing

Title of the research project	Mechanism and targeting therapy for TGF pathway-dependent diffuse-type gastric cancer
Recipient (Institution)	Yoku Hayakawa（Department of Gastroenterology,The University of Tokyo Hospital,）
Journal article / other material	Cell Stem Cell 28, August 5, 2021 https://doi.org/10.1016/j.stem.2021.05.012
Title of the paper	Stem cells and origins of cancer in the upper gastrointestinal tract

Title of the research project	Mechanisms involved in regulation of osteoclast formation by glucan recognition via immune receptors
Recipient (Institution)	Wataru Ariyoshi（Division of Infections and Molecular Biology,Kyushu Dental University）
Journal article / other material	Molecules 2021, 26, 1982 doi.org/10.3390/molecules26071982
Title of the paper	Biological Effects of β-Glucans on Osteoclastogenesis

Title of the research project	Elucidation of the promotion mechanism in plant shoot regeneration by environmental stimuli
Recipient (Institution)	Sachihiro Matsunaga（Matsunaga Laboratory, Department of Applied Biological Science, Faculty of Science and Technology,Tokyo University of Science）
Journal article / other material	NATURE COMMUNICATIONS (2020) 11:5914 doi.org/10.1038/s41467-020-19621-z
Title of the paper	Subnuclear gene positioning through lamina　association affects copper tolerance
Journal article / other material	Communications biology 14, May 2021 doi.org/10.1038/s42003-021-02106-0
Title of the paper	A live imaging system to analyze spatiotemporal　dynamics of RNA polymerase II modification in Arabidopsis thaliana

Title of the research project	Analyses of pain regulation mechanisms by IL-27
Recipient (Institution)	Hiroki Yoshida（Dept Biomol Sci, Faculty of Medicine,Saga University,Professor）
Journal article / other material	Microbiol Spectr. 2021 Aug 4;e0051121. doi: 10.1128/Spectrum.00511-21
Title of the paper	Entamoeba Chitinase is Required for Mature Round Cyst Formation

Title of the research project	Molecular and neural mechanism associated with social behavior
Recipient (Institution)	Teiichi Furuichi（Department of Biological Science, Faculty of Science and Technology,Tokyo University of science）
Journal article / other material	Front. Cell. Neurosci. 2020, 14: 595607. doi: 10.3389/fncel.2020.595607.
Title of the paper	Comprehensive Profiling of Gene Expression in the Cerebral Cortex and Striatum of BTBRTF/ArtRbrc Mice Compared to C57BL/6J Mice.
Journal article / other material	Cell Tissue Res. 2020, 382(1):125-134. doi: 10.1007/s00441-020-03274-x.
Title of the paper	Journey of brain-derived neurotrophic factor: from intracellular trafficking to secretion
Journal article / other material	The Journal of Neuroscience, May 19, 2021 doi.org/10.1523/JNEUROSCI.3240-20.2021
Title of the paper	CAPS2 Deficiency Impairs the Release of the Social Peptide Oxytocin, as Well as Oxytocin-Associated Social Behavior
Journal article / other material	Frontiers in Molecular Biosciences, 2022, 9:1040237 Doi: 10.3389/fmolb.2022.1040237
Title of the paper	Loss of CAPS2/Cadps2 leads to exocrine pancreatic cell injury and intracellular accumulation of secretory granules in mice

Title of the research project	Development of H2S-Activatable Near-Infrared-dye Probes: Bioimaging and Therapy
Recipient (Institution)	Yusuke Ishigaki（Laboratory of Organic Chemistry Ⅰ, Department of Chemistry,Hokkaido University）
Journal article / other material	Chem. Commun. 2021, 57, 7201-7214. DOI: 10.1039/D1CC02260A
Title of the paper	Redox-active Tetraaryldibenzoquinodimethanes

Title of the research project	Identification of molecular mechanism underlying drug resistance by tumor-stroma derived exosome
Recipient (Institution)	Takatsugu Ishimoto（Division of Translational Research and Advanced Treatment Against Gastrointestinal Cancer,Kumamoto University Hospital）
Journal article / other material	Cancer Res. 2020; 80(16): 3222-3235 doi: 10.1158/0008-5472.CAN-19-3803
Title of the paper	Extracellular Vesicles from Cancer-Associated Fibroblasts Containing Annexin A6 Induces FAK-YAP Activation by Stabilizing b1 Integrin, Enhancing Drug Resistance

Title of the research project	The ultrastabilization mechanism of amyloid revealed by a protein engineering technique
Recipient (Institution)	Koki Makabe（School of science and engineering, Makabe lab.,Yamagata university）
Journal article / other material	2021 Wiley Periodicals LLC, 8 February 2021 DOI: 10.1002/prot.26063
Title of the paper	Structural analysis of the β-sheet edge of peptide self-assembly using a model protein

Title of the research project	Identification of the lipid species which regulate epidermis differentiation in Arabidopsis
Recipient (Institution)	Mitsutomo Abe（Graduate School of Arts and Sciences,The University of Tokyo）
Journal article / other material	The Company of Biologists, Development (2021) 148, dev194969. doi:10.1242ldev.194969
Title of the paper	Ceramides mediate positional signals in Arabidopsis thaliana protoderm differentiation

FY2018 Grant Recipients

Title of the research project	Fundamental study for GATA3 transcriptional complex and new insight into functional role of type2 innate lymphoid cells to control life-style related disease
Recipient (Institution)	Tanaka Tomoaki（Chiba University, Graduate School Medicine）
Journal article / other material	eNeurologicalSci. 19:100239, 2020 10.1016/j.ensci.2020.100239
Title of the paper	Monoamine oxidase B rs1799836 G allele polymorphism is a risk factor for early development of levodopa-induced dyskinesia in Parkinson's disease.
Journal article / other material	Endcrine Journal. 67(8):841-852 2020. doi.org/10.1507/endocrj.EJ19-0617
Title of the paper	A multicenter, phase 2 study to evaluate the efficacy and safety of osilodrostat, a new 11β-hydroxylase inhibitor, in Japanese patients with endogenous Cushing’s syndrome other than Cushing’s disease.
Journal article / other material	J Clin Endocrinol Metab., Epub., 105(2): dgz073, 202 DOI:10.1210/clinem/dgz073
Title of the paper	A case of Hashimoto’s thyroiditis with multiple drug resistance and high expression of efflux transporters.

Title of the research project	Importance of tissue-resident memory T cells in mucosal tissue
Recipient (Institution)	Iijima Norifumi（National Institutes of Biomedical Innovation, Health and Nutriti）
Journal article / other material	Curr Top Microbiol Immunol. 2020, 426, 83 10.1007/82_2020_213.
Title of the paper	Memory Lymphocyte Clusters in Genital Immunity: Role of Tissue-Resident Memory T Cells (TRM).
Journal article / other material	Neurochemical Research. 2021 Jul 1. doi: 10.1007/s11064-021-03384-0.
Title of the paper	Distinct expression of SLM2 underlies splicing-dependent trans-synaptic signaling of neurexin across GABAergic neuron subtypes

Title of the research project	Analysis of cell lineage and transcriptional regulation during ventricular development of heart
Recipient (Institution)	Watanabe Yusuke（Molecular Phys lab, National Cerebral and Cardiovascular Center）
Journal article / other material	Dev Biol. 2020;461(2):124-131. doi: 10.1016/j.ydbio.2020.02.001.
Title of the paper	Expression of Hey2 transcription factor in the early embryonic ventricles is controlled through a distal enhancer by Tbx20 and Gata transcription factors
Journal article / other material	J Biol Chem. 2020;295(51):17632-17645. doi: 10.1074/jbc.RA120.015003.
Title of the paper	Importance of endothelial Hey1 expression for thoracic great vessel development and its distal enhancer for Notch-dependent endothelial transcription
Journal article / other material	Dev Growth Differ. 2021;63(1):82-92. doi: 10.1111/dgd.12707.
Title of the paper	A role of Hey2 transcription factor for right ventricle development through regulation of Tbx2-Mycn pathway during cardiac morphogenesis

Title of the research project	Pathophysiologic role of a novel microenvironment that prolongs tissue damage in acute kidney injury
Recipient (Institution)	Suganami Takayoshi（Dept. of Molecular Medicine and Metabolism, Nagoya University）
Journal article / other material	J Exp Med. 2020; 217: e20192230 doi: 10.1084/jem.20192230.
Title of the paper	C-type lectin Mincle mediates cell death-triggered inflammation in acute kidney injury.

Title of the research project	Development of new base editor systems
Recipient (Institution)	Yachie Nozomu（RCAST, The University of Tokyo）
Journal article / other material	Nature Biotechnology 38, 865-869 (2020) doi.org/10.1038/s41587-020-0509-0
Title of the paper	Base editors for simultaneous introduction of C-to-T and A-to-G mutations.

Title of the research project	Study on the circadian rhythm system regulated by intracellular carbon monoxide
Recipient (Institution)	Kitagishi Hiroaki（Faculty of Science and Engineering, Doshisha University）
Journal article / other material	Chem.Asia J. 2019.14.3320-3328 doi.org/10.1002/asia.201900983
Title of the paper	Supramolecular Complexation in Biological Media: NMR Study on Inclusion of an Anionic Tetraarylporphyrin into a Per‐O ‐Methylated β‐Cyclodextrin Cavity in Serum, Blood, and Urine
Journal article / other material	Communications Biology, 4, 425 (2021) (15 pages) DOI: 10.1038/s42003-021-01880-1
Title of the paper	Sensitive quantification of carbon monoxide (CO) in vivo reveals a protective role of circulating hemoglobin in CO intoxication
Journal article / other material	Polymer Journal volume 54, pages 465-472 (2022) DOI: 10.1038/s41428-021-00591-y
Title of the paper	Capture of carbon monoxide using a heme protein model: from biomimetic chemistry of heme proteins to physiological and therapeutic applications

Title of the research project	The RNA-based mechanism underlying pathophysiology in the neurological diseases
Recipient (Institution)	Iijima Takatoshi（Tokai University Institute of Innovative Science and Technology）
Journal article / other material	Neurochemical Research (in revision)
Title of the paper	Distinct expression of SLM2 underlies splicing-dependent trans-synaptic signaling of neurexin across GABAergic neuron subtypes
Journal article / other material	iScience. 22:318-335. (2019) doi: 10.1016/j.isci.2019.11.028.
Title of the paper	SAM68-Specific Splicing Is Required for Proper Selection of Alternative 3' UTR Isoforms in the Nervous System.

Title of the research project	Elucidation of the molecular basis and physiological significance of autophagic degradation of the nuclear pore complex
Recipient (Institution)	Nakatogawa Hitoshi（Sch. of Life Sci. and Tech., Tokyo Institute of Technology）
Journal article / other material	Journal of Cell Biology (2020) 219, 7, e201910063 doi.org/10.1083/jcb.201910063
Title of the paper	TORC1 inactivation stimulates autophagy of nucleoporin and nuclear pore complexes

Title of the research project	Identification of glycosyltransferases involved in biosynthesis of pectin in plant cell wall
Recipient (Institution)	Ishimizu Takeshi（Dept. of Biotechnol., Col. of Life Sci., Ritsumeikan Univ.）
Journal article / other material	Plant Physiology and Biochemistry (2019) 142, 173-178 10.1016/j.plaphy.2019.07.008
Title of the paper	Rhamnogalacturonan I galactosyltransferase: Detection of enzyme activity and its hyperactivation
Journal article / other material	Frontiers in Plant Science (2020) 11, 997 10.3389/fpls.2020.00997
Title of the paper	Diversity of Pectin Rhamnogalacturonan I Rhamnosyltransferases in Glycosyltransferase Family 106
Journal article / other material	Journal of the Japanese Society of Applied Glycoscience (2020) 10, 96-102 doi.org/10.5458/bag.10.2_96
Title of the paper	Toward the Elucidation of Molecular Mechanism for Biosynthesis of Pectin in Plant Cell Wall

Title of the research project	RNA base modification and RNA processing regulate the maintenance and development of germline stem cells
Recipient (Institution)	Kai Toshie（Graduate School of Frontier Biosciences, Osaka University）
Journal article / other material	PLOS ONE、2020、Vol.15、e0231114 10.137/journal.pone.0231114
Title of the paper	Drosophila MARF1 ensures proper oocyte maturation by regulating nanos expression
Journal article / other material	Cell Reports、2020、10;33(6):108380、 doi: 10.1016/j.celrep.2020.108380
Title of the paper	Modulation of Ago2 Loading by Cyclophilin 40 Endows a Unique Repertoire of Functional miRNAs during Sperm Maturation in Drosophila

Title of the research project	Unveiling a novel regulatory mechanism of angiogenesis by intraluminal pressure
Recipient (Institution)	Fukuhara Shigetomo（Inst. of Adv. Med. Sci., Nippon Medical School, Professor）
Journal article / other material	Kidney360 April 2022, 3 (4) 700-713 DOI: https://doi.org/10.34067/KID.0005962021
Title of the paper	Blood flow regulates glomerular capillary formation in zebrafish pronephros.
Journal article / other material	Nat. Commun. 2022 May 12;13(1):2594. doi: 10.1038/s41467-022-30197-8.
Title of the paper	Mechanical loading of intraluminal pressure mediates wound angiogenesis by regulating the TOCA family of F-BAR proteins.

Title of the research project	Physiological roles and molecular mechanisms underlying the synaptic plasticity in the dentate gyrus
Recipient (Institution)	Hashimotodani Yuki（Doshisha University, Organization for Research Initiatives and Development）
Journal article / other material	Proceedings of the National Academy of Sciences of the United States of America 119(13) e2119636119 2022年/ doi.org/10.1073/pnas.2119636119
Title of the paper	Excitatory selective LTP of supramammillary glutamatergic/GABAergic cotransmission potentiates dentate granule cell firing

Title of the research project	The role of desmoplakin in the antidepressant-like effects in the hippocampus
Recipient (Institution)	SegiNishida Eri（Segi lab, Dept. of Biol. Sci. and Tech., Tokyo University of Sci）
Journal article / other material	Pharmacol Biochem Behav. 186:172767. 2019. 10.1016/j.pbb.2019.172767
Title of the paper	Search for factors contributing to resistance to the electroconvulsive seizure treatment model using adrenocorticotrophic hormone-treated mice.
Journal article / other material	Neuropsychopharmacol Rep. 41:56-64.2021 10.1002/npr2.12156
Title of the paper	Electroconvulsive seizures lead to lipolytic-induced gene expression changes in mediobasal hypothalamus and decreased white adipose tissue mass.

Title of the research project	Identification and molecular mechanism of novel calcium transport disease ;possible therapeutic target for bone mineralization defects
Recipient (Institution)	Suzuki Yoshiro（Div. Cell Signaling, Nat. Inst. Physiol. Sci.）
Journal article / other material	J Physiol Sci (2020) 70(1) 33 - 33 10.1186/s12576-020-00761-2
Title of the paper	Novel TRPV6 mutations in the spectrum of transient neonatal hyperparathyroidism

Title of the research project	Projection-specific circuit formation in the developing cerebral cortex
Recipient (Institution)	Tagawa Yoshiaki（Dept. Physiology, Faculty of Medicine, Kagoshima University）
Journal article / other material	Cerebral Cortex, 2021, 31, 1307-1315 doi:10.1093/cercor/bhaa297
Title of the paper	Long-range interhemispheric projecion neurons show biased
Journal article / other material	Frontiers in Neuroscience, 2021, 15, Article 747951, doi: 10.3389/fnins.2021.747951
Title of the paper	Involvement of Calcium-Dependent Pathway and β Subunit-Interaction in Neuronal Migration and Callosal Projection Deficits Caused by the Cav1.2 I1166T Mutation in Developing Mouse Neocortex

Title of the research project	Peptide foldamers in drug discovery
Recipient (Institution)	Demizu Yosuke（Division of Organic Chemistry, NIHS）
Journal article / other material	ChemMedChem,14,22（2019) doi.org/10.1002/cmdc.201900460
Title of the paper	Development of Amphipathic Antimicrobial Peptide Foldamers Based on Magainin 2 Sequence
Journal article / other material	MedChemComm,10,6,831-1044（2019） doi.org/10.1039/c9md00166b
Title of the paper	Rational design of novel amphipathic antimicrobial peptides focused on the distribution of cationic amino acid residues

Title of the research project	Research on metabolic reprogramming induced by cancer development and inflammation
Recipient (Institution)	Taniguchi Koji（Department of Microbiology and Immunology, Keio University）
Journal article / other material	Mol Cancer Res 2020 18(12):1876-1888. doi: 10.1158/1541-7786.MCR-20-0186
Title of the paper	Autocrine Leukemia Inhibitory Factor Promotes Esophageal Squamous Cell Carcinoma Progression via Src Family Kinase-Dependent Yes-Associated Protein Activation
Title of the paper	Int J Mol Sci. 2021 Feb 24;22(5):2238. doi: 10.3390/ijms22052238.
Journal article / other material	Immunomodulation by Inflammation during Liver and Gastrointestinal Tumorigenesis and Aging
Title of the paper	Int J Mol Sci. 2021 May 21;22(11):5421. doi: 10.3390/ijms22115421.
Journal article / other material	Inflammation-Induced Tumorigenesis and Metastasis

FY2017 Grant Recipients

Title of the research project	Epigenetic and Metabolic Changes on transdifferentiation of white adipocytes
Recipient (Institution)	Takeshi Inagaki（Institute for Molecular and Cellular Regulation, Gunma University, professor）
Journal article / other material	Endocrine Journal vol.66,No2(February 2019) Published by The Japan Endocrine Society
Title of the paper	Epigenetic regulation of beige adipocyte fate by histone methylation
Journal article / other material	Diabetology International(2018) 9:215-223
Title of the paper	Histone demethylases regulate adipocyte thermogenesis

Title of the research project	Neural circuits that regulate glucose metabolism between hypothalamus and peripheral organs
Recipient (Institution)	Kunio Kondoh（National Institute for Physiological Sciences, Assistant Professor ）
Journal article / other material	Neuroscience Bulletin,20 September 2018 doi:/10.1007/s12264-019-00374-9
Title of the paper	Trans-synaptic Neural Circuit-Tracing with Neurotropic Viruses

Title of the research project	Heart Cell Molecular Atlas Project to dissect the regulatory mechanisms of circulatory homeostasis
Recipient (Institution)	Seitaro Nomura（The University of Tokyo Hospital, Assistant Professor）
Journal article / other material	Nature Communications volume 9, Article number: 4435 (2018)
Title of the paper	Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure
Journal article / other material	Journal of Molecular and Cellular Cardiology, March 2019Volume 128, Pages 77-89
Title of the paper	High-throughput single-molecule RNA imaging analysis reveals heterogeneous responses of cardiomyocytes to hemodynamic overload

Title of the research project	Study on the enantioselective total synthesis of dragmacidin E: a natural product with high potential for medicinal chemistry researches
Recipient (Institution)	Tetsuhiro Nemoto（Graduate School of Pharmaceutical Sciences, Chiba University, Professor）
Journal article / other material	ASIAN JOURNAL OF ORGANIC CHEMISTRY Vol.7,2018,P1730-1742
Title of the paper	Synthetic Methods for 3,4‐Fused Tricyclic Indoles via Indole Ring Formation

Title of the research project	Development of combination therapy targeting on tumor endothelial cells
Recipient (Institution)	Takahisa Murata（The University of Tokyo, Associate Professor）
Journal article / other material	THE FASEB JOURNAL,vol33 doi/10.1096/201802153R
Title of the paper	Hematopoietic prostaglandin D synthase-derived prostaglandin D2 ameliorates adjuvant-induced joint inflammation in mice
Journal article / other material	JCI Insight. 2018;3(23):e120706,doi/10.1172
Title of the paper	Inhibition of stromal cell-derived factor-1α/CXCR4 signaling restores the blood-retina barrier in pericyte-deficient mouse retinas
Journal article / other material	The journal of pathology ,2019,Vol.248(3),p.280-290
Title of the paper	L-PGDS-derived PGD2attenuates acute lung injury by enhancing endothelial barrier formation

Title of the research project	Development of super resolution chemical imaging microscopy
Recipient (Institution)	Takahashi Yasufumi（Kanazawa University）
Journal article / other material	Analytical Chemistry, 2021, 93(13), 5383-5393 doi.org/10.1021/acs.analchem.0c04097
Title of the paper	Nanoscale Visualization of Morphological Alteration of Live-Cell Membranes by the Interaction with Oligoarginine Cell-Penetrating Peptides
Journal article / other material	Analytical Chemistry, 2020, 92(2), 2159-2167 doi.org/10.1021/acs.analchem.9b04775
Title of the paper	High-Speed SICM for the Visualization of Nanoscale Dynamic Structural Changes in Hippocampal Neurons

Title of the research project	Exploratory analysis to evaluate mutation spectrum of circulating tumor DNA from metastatic breast cancer treated with aromatase inhibitors
Recipient (Institution)	SiewKee Low（Japanese Foundation for Cancer Research）
Journal article / other material	Breast Cancer Res Treat. 2020 Apr;180(2):331-341. 10.1007/s10549-019-05512-5
Title of the paper	Clinical significance of gene mutation in ctDNA analysis for hormone receptor-positive metastatic breast cancer

Title of the research project	Functional Analysis of Chk1 Targets for Breast Cancer Treatment
Recipient (Institution)	Shimada Midori（Yamaguchi University, Joint Faculty of Veterinary Medicine）
Journal article / other material	PNAS. 2021; 118: e211425811 doi: 10.1073/pnas.2114258118
Title of the paper	Calcineurin regulates the stability and activity of estrogen receptor α.

Title of the research project	Direct reprogramming into cardiac pacemaker cells for a novel regenerative medicine for arrhythmias
Recipient (Institution)	Nakao Shu（Ritsumeikan University）
Journal article / other material	Biotechnol J 2019;2019:e1900052 10.1002/biot.201900052
Title of the paper	Chimeric G-CSF receptor-mediated STAT3 activation contributes to efficient induction of cardiomyocytes from mouse induced pluripotent stem cells.

Title of the research project	Development of apoptosis induction method with spatiotemporal control using microRNAs.
Recipient (Institution)	Watanabe Kazunori（Okayama University）
Journal article / other material	Scientific reports, 2021, 11, 14936 doi 10.1038/s41598-021-94249-7.
Title of the paper	Photocontrolled apoptosis induction using precursor miR-664a and an RNA carrier-conjugated with photosensitizer

Title of the research project	Molecular mechanism of store-operated Ca2+ entry signalosome and its physiological significance
Recipient (Institution)	Baba Yoshihiro（Medical Institute of Bioregulation, Kyushu University）
Journal article / other material	The Journal of Biochemistry, mvab063, in press 10.1093/jb/mvab063
Title of the paper	ER membrane protein complex 1 interacts with STIM1 and regulates store-operated Ca2+ entry

Title of the research project	Decoding the epigenome program which defines normal and tumor endothelial cells
Recipient (Institution)	Suzuki Hiromu（Sapporo Medical University）
Journal article / other material	Cancer Science, 2020, 111(5):1631-1644 10.1111/cas.14360.
Title of the paper	Upregulation of adipocyte enhancer-binding protein 1 in endothelial cells promotes tumor angiogenesis in colorectal cancer.

Title of the research project	Elucidation of long non-coding RNA family induced by molecular targeting anti-cancer drugs
Recipient (Institution)	Kondo Shigetada（Osaka Prefecture University）
Journal article / other material	Neuroscience Bulletin 2019年　33巻　909-920頁 10.1007/s12264-019-00374-9
Title of the paper	Trans-synaptic Neural Circuit-Tracing with Neurotropic Viruses

Title of the research project	Development of anti-metastatic therapy based on the regulation of vascular integrity
Recipient (Institution)	Shindo Takayuki（Shinshu University Graduate School of Medicine）
Journal article / other material	Peptides. 110 10-18. 2018 10.1016/j.peptides.2018.10.006
Title of the paper	RAMP3 deficiency enhances postmenopausal obesity and metabolic disorders
Journal article / other material	Am J Pathol. 189(2):449-466. 2019 10.1016/j.ajpath.2018.10.021
Title of the paper	Development of a novel model of central retinal vascular occlusion and the therapeutic potential of the adrenomedullin-RAMP2 system
Journal article / other material	Am J Pathol. 191(4):652-668, 2021 10.1016/j.ajpath.2020.12.012
Title of the paper	Adrenomedullin-RAMP2 system ameliorates subretinal fibrosis by suppressing epithelial-mesenchymal transition in age-related macular degeneration

Title of the research project	Mechanisms underlying commitment to thymic epithelial cells preventing onset of autoimmune diseases
Recipient (Institution)	Akiyama Taishin（RIKEN Center for Integrative Medical Science, Team leader）
Journal article / other material	Sci Rep. 2019 Dec 27;9(1):19866. 10.1038/s41598-019-56432-9.
Title of the paper	Impact of spaceflight on the murine thymus and mitigation by exposure to artificial gravity during spaceflight
Journal article / other material	Sci Rep. 2019 May 21;9(1):7654 10.1038/s41598-019-44067-9
Title of the paper	Down-regulation of GATA1-dependent erythrocyte-related genes in the spleens of mice exposed to a space travel

Title of the research project	Regulation of cellular functions by the nuclelous as a stress sensor
Recipient (Institution)	Kimura Keiji（University of Tsukuba）
Journal article / other material	Nucleic Acids Research、2020、48、12、6583-6596 10.1093/nar/gkaa449.
Title of the paper	Identification of a novel nucleolar protein complex required for mitotic chromosome segregation through centromeric accumulation of Aurora B
Journal article / other material	Biochem Biophys Res Commun. 2022 Jan 15;588:133-139. doi: 10.1016/j.bbrc.2021.12.059.
Title of the paper	SF3B14 is involved in the centrosome regulation through splicing of TUBGCP6 pre-mRNA

Title of the research project	Tras-omics approach to elucidate cellular signaling pathways in vascular development, morphogenesis and disease
Recipient (Institution)	Nakagawa Osamu（National Cerebral and Cardiovascular Center Research Institute）
Journal article / other material	genesis. 59(4): e23416, 2021. 10.1002/dvg.23416
Title of the paper	Tmem100-BAC-EGFP mice to selectively mark and purify embryonic endothelial cells of large caliber arteries in mid-gestational vascular formation.
Journal article / other material	Dev. Growth Differ. 63(1): 82-92, 2021. 10.1111/dgd.12707
Title of the paper	A role of Hey2 transcription factor for right ventricle development through regulation of Tbx2-Mycn pathway during cardiac morphogenesis
Journal article / other material	J. Biol. Chem. 295(51):17632-17645, 2020. 10.1074/jbc.RA120.015003
Title of the paper	Importance of endothelial Hey1 expression for thoracic great vessel development and its distal enhancer for Notch-dependent endothelial transcription.
Journal article / other material	Genes Cells. 26(8): 611-626, 2021 doi: 10.1111/gtc.12874
Title of the paper	ETS- dependent enhancers for endothelial- specific expression of

Title of the research project	Studies on formation and function of extracellular DNA fibers
Recipient (Institution)	Saitoh Hisato（Kumamoto University）
Journal article / other material	Sci Rep 9, 8451 (2019). doi.org/10.1038/s41598-019-44817-9
Title of the paper	Nanosecond pulsed electric fields induce extracellular release of chromosomal DNA and histone citrullination in neutrophil-differentiated HL-60 cells.
Journal article / other material	CellBio, 2020, 9, 14-28. doi: 10.4236/cellbio.2020.91002.
Title of the paper	Three Types of Nuclear Envelope Assemblies Associated with Micronuclei.
Journal article / other material	Bioscience, Biotechnology, and Biochemistry, Volume 84, Issue 8, 2 August 2020, Pages 1685-1688, doi.org/10.1080/09168451.2020.1756737
Title of the paper	A fluorescence method to visualize the nuclear boundary by the lipophilic dye DiI

Title of the research project	5-HT2A receptor agonists in treatment to psychiatric disorders
Recipient (Institution)	Ibi Daisuke（Meijo University）
Journal article / other material	Neurotoxicology and Teratology、2019、76、106837 10.1016/j.ntt.2019.106837
Title of the paper	Paternal valproic acid exposure in mice triggers behavioral alterations in offspring

Title of the research project	A novel oxytocin neuronal system for regulating lactating behavior in mice
Recipient (Institution)	Muroi Yoshikage（Obihiro University of Agriculture and Veterinary Medicine）
Journal article / other material	Hormones and Behavior, 2020, 124, 104773 10.1016/j.yhbeh.2020.104773
Title of the paper	Oxytocin in the dorsal raphe nucleus antagonizes the inhibition of maternal care induced by food deprivation
Journal article / other material	Behavioral Neuroscience, 2021, Vol. 135, No. 3, 359-368 doi.org/10.1037/bne0000374
Title of the paper	Regulation of maternal care by corticotropin-releasing factor receptors in the dorsal raphe nucleus in mice.

Title of the research project	Molecular mechanism for the bifurcation of thymic epithelial cells
Recipient (Institution)	Ohigashi Izumi（Institute of Advanced Medical Science, University of Tokushima ）
Journal article / other material	Cell Reports (2019) 29:2901-2916 doi: 10.1016/j.celrep.2019.10.079
Title of the paper	Trans-omics impact of thymoproteasome in cortical thymic epithelial cells
Journal article / other material	Journal of Biological Chemistry (2020) 295:1658-1672 doi: 10.1074/jbc.RA119.011144
Title of the paper	PITHD1 is a proteasome-interacting protein essential for male fertilization
Journal article / other material	Blood advances (2021) 5:99-112 doi: 10.1182/bloodadvances.2020003192
Title of the paper	Medullary stromal cells synergize their production and capture of CCL21 for T-cell emigration from neonatal mouse thymus
Journal article / other material	eLife (2022) 11:e69088. doi.org/10.7554/eLife.69088
Title of the paper	Fine-tuning of β-catenin in mouse thymic epithelial cells is required for postnatal T-cell development

Title of the research project	Novel treatment strategy targeting CCR1-positive myeloid cells in colorectal cancer
Recipient (Institution)	Kawada Kenji（Kyoto University）
Journal article / other material	Clin Cancer Res. 2019;25(9):2887-2899. 10.1158/1078-0432.CCR-18-3684.
Title of the paper	Loss of SMAD4 promotes colorectal cancer progression by recruiting tumor-associated neutrophils via CXCL1/8-CXCR2 axis

Title of the research project	Design principle for specific chemical probes toward 3D neuropathology
Recipient (Institution)	Tainaka Kazuki（Brain Research Institute, Niigata University）
Journal article / other material	Cell Reports, 2018, 24(8), 2196-2210.e9. 10.1016/j.celrep.2018.07.056.
Title of the paper	Chemical Landscape for Tissue Clearing Based on Hydrophilic Reagents

FY2016 Grant Recipients

Title of the research project	Identification of novel neural processing mechanism by using single transcriptome analysis
Recipient (Institution)	Akane Ohta（Konan University, Researcher）
Journal article / other material	Cryobiology and Cryotechnology 64.2_53 (2019) doi./10.20585/
Title of the paper	Molecular and Cellular Network Systems Underlying Cold Tolerance of Caenorhabditis elegans

Title of the research project	Genome-wide analysis of transcriptional and translational regulation by RNA binding protein PSF in prostate cancer
Recipient (Institution)	Kenichi Takayama Department of Functional Biogerontology, Tokyo Metropolitan Inst, Researcher）
Journal article / other material	Oncogene 37, 2165-2180, (2018) https://doi.org/10.1038/s41388-017-0095-x
Title of the paper	TRIM25 enhances cell growth and cell survival by modulating p53 signals via interaction with G3BP2 in prostate cancer

Title of the research project	Study on the Mechanism of Sex Determination in Germline Stem Cells
Recipient (Institution)	Minoru Tanaka（Nagoya University, Professor）
Journal article / other material	PLOS Genetics 14, (2018) https://doi.org/10.1371/journal.pgen.1007259
Title of the paper	Germ cells in the teleost fish medaka have an inherent feminizing effect

Title of the research project	Elucidation of the onset mechanism of myeloproliferative neoplasm through the erythropoietin receptor
Recipient (Institution)	Megumi Tago（Keio University, Associate Professor）
Journal article / other material	European Journal of Pharmacology 825, 1-9, (2018) https://doi.org/10.1016/j.ejphar.2018.02.012
Title of the paper	A major component of vitamin E, α-tocopherol inhibits the anti-tumor activity of crizotinib against cells transformed by EML4-ALK

Title of the research project	Selective information routing in hippocampal network
Recipient (Institution)	Mizuseki Kenji（Osaka City University Graduate School of Medicine, Professor）
Journal article / other material	Neuroscience Research 118, 30-47, (2017) http://dx.doi.org/10.1016/j-neures.2017.04.018
Title of the paper	Hippocampal information proccessing across sleep/wake cycles

FY2015 Grant Recipients

Title of the research project	Control of host immune responses through innate pattern-recognition receptors that recognize Mycobacterium tuberculosis virulence lipids
Recipient (Institution)	Hiromitsu Hara, Kagoshima University Graduate School of Medical and Dental Sciences, Professor
Journal article / other material	Nature Communications 6:5555 doi:10.1038/ncomms6555
Title of the paper	Clustering of CARMA1 through SH3-GUK domain interactions is required for its activation of NF-κB signaling

Title of the research project	Molecular mechanism of plant cell growth via NIMA-related kinases
Recipient (Institution)	Hiroyasu Motose, Okayama University, Department of Biological Science, Graduate School of Natural Science & Technology, Associate Professor
Journal article / other material	Development (2018) 145, dev154617 doi:10.1242/dev.154617
Title of the paper	An evolutionarily conserved NIMA-related kinase directs rhizoid tip growth in the basal land plant Merchantia polymorpha
Journal article / other material	Scientific Report 7, 7826 doi:10.1038/s41598-017-08453-5
Title of the paper	Directional cell expansion requires NIMA-related kinase 6 (NEK6)-mediated cortical microtubule destabilization

Title of the research project	Analysis of a signal through ER required for the induction of axon regeneration
Recipient (Institution)	Naoki Hisamoto, Nagoya university Graduate school of Science, Associate Professor
Journal article / other material	PLoS 12(12):e1006475 doi:10.1371/journal.pgen.1006475
Title of the paper	The C. elegans Discoidin Domain Receptor DDR-2 Modulates the Met-like RTK-JNK Singnaling Pathway in Axon Regeneration

Title of the research project	Development of molecular delivery system using cell membrane penetrating DNA nanostructures
Recipient (Institution)	Masayuki Endo, Kyoto University, Institute for Integrated Cell-Material Sciences (WPI-iCeMS),
Journal article / other material	Chem. Eur. J 23, 3979-3985 (2017) doi:10.1002/chem.201605616
Title of the paper	A photoregulated DNA-Based Rotary System and Direct Observation of Its Rotational Movement

Title of the research project	Functional significance of Chandelier cell in cortical microcircuit
Recipient (Institution)	Yoshiyuki Kubota, National Institute for Physiological Sciences, Associate professor
Journal article / other material	Front Neural Circuits 10, 27 (2016) doi:10.3389/fncir.2016.00027
Title of the paper	The Diversity of Cortical Inhibitory Synapses
Journal article / other material	Nat Commun 9, 437 (2018) doi:10.1038/s41467-017-02768-7
Title of the paper	A catructurerbon nanotube tape for serial-section electron microscopy of brain ultra

Title of the research project	Cortical synaptic plasticity for coexistence of chronic pain and anxiety neurosis
Recipient (Institution)	Kohei Koga, Hirosaki University Department of Neurophysiology, Assistant
Journal article / other material	J. Neurochem. 141 486-498 (2017)
Title of the paper	Neuronal and microglial mechanisms for neuropathic pain in the spinal dorsal horn and anterior cingulate cortex

Title of the research project	Functional analysis of a novel silencing mechanism in higher plants
Recipient (Institution)	Kei-ichiro Mishiba, Graduate School of Life and Environmental Science, Osaka Prefecture University, Associate
Journal article / other material	Science Direct 1860, 861-869 (2017) https:doi.org/10.1016/j.bbagrm.2017.06.001
Title of the paper	Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms

Title of the research project	The origin of animal multicellular system an approach from genome editing of unicellular holozoans
Recipient (Institution)	Hiroshi Suga, Prefectural University of Hiroshima, Faculty of Life and Environmental Sciences, Associate Professor
Journal article / other material	eLife 2017 6:e26036 doi:10.7554/eLife.26036
Title of the paper	Dynamics of genomic innovation in the unicellular ancestry of animals

Title of the research project	Regulating microtubule arrays for neuronal dendrite growth and for neuronal regeneration
Recipient (Institution)	Adrian Moore（RIKEN Center for Brain Science）
Journal article / other material	Plant Physiology,182,1979－1990（2020）
Title of the paper	Atypical Myosin Tunes Dendrite Arbor Subdivision

FY2014 Grant Recipients

Title of the research project	Effect of dendritic cell based vaccine against highly virulent cryptococcal infection
Recipient (Institution)	Yuki Kinjo (National Institute of Infectious Diseases, Department of Chemotherapy and Mycoses, LaboratoryHead)
Journal article / other material	Frontiers in Cellular and infection Microbiology 5:101 Doi: 10.3389/fcimb.2015.00101 (2016)
Title of the paper	Evasion of innate immune responses by the highly virulent Cryptococcus gatti by altering capsule glucuronoxylomannan structure
Journal article / other material	J Infect Chemother., 21, 831-6 (2015)
Title of the paper	Interferon-γ promotes phagocytosis of Cryptococcus neoformans but not Cryptococcus gatti by murine macrophages
Journal article / other material	Vaccine Design: methods and Protocols: volume 1: vaccines for Human Diseases, method in Molecular Biology, vol 1.1403, DOI 10.1007/978-1-49393387-7_30
Title of the paper	Dendric cell-based vaccine against fungal infection

Title of the research project	Nano scale analysis of lipid molecules of biomembrane topology
Recipient (Institution)	Akikazu Fujita (Kagoshima University, Joint Faculty of Veterinary Medicine, Professor)
Journal article / other material	Biochimica Biophysica Acta, 1858, 1298-305 (2016)
Title of the paper	Nanoscale analysis reveals agonist-sensitive and heterogeneous pools of phosphatidylinositol 4-phosphate in the plasma membrane

Title of the research project	Positive feed-forward loop of mTOR complex links cellular metabolism to targeted therapy resistance
Recipient (Institution)	Kenta Masui (Laboratory of Neuropathology, Tokyo Metropolitan Institute of Medical Science, Chief Researcher)
Journal article / other material	Brain pathology, 25, 755-9 (2015)
Title of the paper	mTORC2 and metabolic reprogramming in GBM: at the interface of genetics and environment
Journal article / other material	www.pnas.org/cgi/doi/10.1073/pnas.1511759112
Title of the paper	Glucose-dependent acetylation of rictor promotes targeted cancer therapy resistance

Title of the research project	Analysis of molecular mechanisms for cell fate determination of retinal interneurons
Recipient (Institution)	Rikako Sanuki (Osaka University, Institute for Protein Research, Assistant Professor)
Journal article / other material	J Neuroscience, 35, 8004-20 (2015)
Title of the paper	Prdm13 regulates subtype specification of retinal amacrine interneurons and modulates visual sensitivity
Journal article / other material	Molecular and Cellular Biology, 35, 2583-96 (2015)
Title of the paper	Rax homoprotein regulates photoreceptor cell maturation and survival in association with Crx in the postnatal mouse retina

Title of the research project	Drug discovery for neuropathic pain from processed aconite root
Recipient (Institution)	Toshiaki Makino (Nagoya City University,Graduate School of Pharmaceutical Sciences, Professor)
Journal article / other material	Journal of Ethnopharmacoloy, 186, 44-52 (2016)
Title of the paper	Processed aconite root and its active ingredient neoline may alleviate oxaliplatin-induced peripheral neuropathic pain

Title of the research project	Development of a comprehensive synthetic strategy and study of biological activity of yuzurimine alkaloids
Recipient (Institution)	Ichiro Hayakawa (Graduate School of Natural Science and Technology, Okayama University, Associate Professor)
Journal article / other material	Chem. Commun., 51, 11568-71 (2015)
Title of the paper	Construction of the [6-7-5-5] tetracyclic core of all the carbocyclic frameworks of yuzurimine-type alkaloids
Journal article / other material	Org. Biomol. Chem., 13, 9969-76 (2015)
Title of the paper	Synthesis and structure-activity relationships for cytotoxicity and apoptosis-inducing activity of (+)-halichonine B

Title of the research project	Development of novel therapy for peripheral artery disease using ApoA-I mimetic peptide
Recipient (Institution)	Satoshi Imaizumi (Fukuoka University School of Medicine, Assistant Professor)
Journal article / other material	International Journal of Cardiology, 207, 317-25 (2016)
Title of the paper	The ApoA-I mimetic peptide FAMP promotes recovery from hindlimb ischemia through a nitric oxide (NO)-related pathway

Title of the research project	Regulation mechanisms of retroelements by RNA virus
Recipient (Institution)	Tomoyuki Honda (Institute for Virus Research, Kyoto University, Assistant Professor)
Journal article / other material	Cell reports, 12, 1948-54 (2015)
Title of the paper	Transcription profiling demonstrates epigenetic control of non-retroviral RNA virus-derived elements in the human genome
Journal article / other material	Frontiers in Chemostry, 4, doi:10.3389/fchem.2016.00021
Title of the paper	Links between human LINE-1 retrotransposons and hepatitis virus-related hepatocellular carcinoma
Journal article / other material	Mobile Genetic Elements, 6, Doi: 10.1080/2159256X.2016. 1165785
Title of the paper	Endogenous non-retroviral RNA virus elements evidence a novel type of antiviral immunity
Journal article / other material	Nature Scientific reports, 6, 26154, Doi: 10.1038/srep26154
Title of the paper	Long-term expression of miRNA for RNA interface using a novel vector system based on a negative-strand RNA virus

Title of the research project	Research on the regulation of chronic inflammatory disease by plasmacytoid dendritic cells
Recipient (Institution)	Hideaki Takagi (Faculty of Medicine, University of Miyazaki, Assistant Professor)
Journal article / other material	Nature Communications, 7, 11273,Doi:10.1038/nocommons11273
Title of the paper	Plasmacytoid dendritic cells orchestrate TLR7-mediated　innate and adaptive immunity for the initiation of autoimmune inflammation

Title of the research project	Genome-wide screening of endocytosis of GPCR
Recipient (Institution)	Junko Toshima (Faculty of Science And Engineering, Waseda University, Associate Professor)
Journal article / other material	Biochemical and Biophysical Research Communications, xxx, 1-7 (2016).doi.org/10.1016/j.bbrc.2016.05.099
Title of the paper	Lipid droplet proteins, Lds1p, Lds2p and Rrt8p, are implicated in membrane protein transport associated with ergosterol
Journal article / other material	Journal of Cell Science, 129, 367-79 (2016), doi:10.1242/jcs.176651
Title of the paper	Srv2/CAP is required for polarized actin cable assembly and patch internalization during clathrin-mediated endocytosis

FY2013 Grant Recipients

Title of the research project	CARTS-mediated protein transport from the Golgi complex to the cell surface
Recipient (Institution)	Yuichi Wakana（Tokyo University of Pharmacy and Life Sciences, School of Life Sciences）
Journal article / other material	Molecular Biology of the Cell, 26, 4686-4699, (2015)
Title of the paper	CARTS biogenesis requires VAP-lipid transfer protein complexes functioning at the endoplasmic reticulum-Golgi interface

Title of the research project	Discovery of New Drug Candidates Based on Development of Site-selective Direct Functionalization of Pyridones
Recipient (Institution)	Koji Hirano（Department of Applied Chemistry, Graduate School of Engineering, Osaka University）
Journal article / other material	Angewandte Communications: 53, 10784-10788 (2014)
Title of the paper	Copper-Mediated C6-Selective Dehydrogenative Heteroarylation of 2-Pyridones with 1,3-Azoles

Title of the research project	Research on Asymmetric Membrane Elongation Critical for Symmetric Cell Division
Recipient (Institution)	Tomomi Kiyomitsu (Nagoya University, Graduate School of Science, Assistant Professor)
Journal article / other material	Trends in Cell Biology, May Vol.25, No.5 286-295 (2015)
Title of the paper	Mechanisms of daughter cell-size control during cell division

Title of the research project	”Memory priming” that determines the start of the critical period for learning
Recipient (Institution)	Koichi Homma (Teikyo University, Faculty of Pharmaceutical Sciences, Professor)
Journal article / other material	Communicative & Integrative Biology: Volume7 Issue5 1-4 October 1 , (2014)
Title of the paper	Expression of the voltage-sensing phosphatase gene in the chick embryonic tissues and in the adult cerebellum

Title of the research project	Dissecting the mechanism of cellular senescence that regulates tumor microenvironment
Recipient (Institution)	Shizue Ohsawa (Kyoto University, Graduate School of Biostudies, Associate Professor)
Journal article / other material	Developmental Biology 395, 19-28(2014)
Title of the paper	Loss of Rab5 drives non-autonomous cell proliferation through TNF and Ras signaling in Drosophila
Journal article / other material	Nature Communications DOI:10.1038/ncomms6264 (2014)
Title of the paper	Mitochondrial defects trigger proliferation of neighbouring cells via a senescence-associated secretory phenotype in Drosophila

Title of the research project	Development of novel treatment strategies targeting the R-spondin-LGR5 axis of brain tumor stem cells
Recipient (Institution)	Ryo Nasu (Kyoto Prefectural University of Medicine, Assistant Professor)
Journal article / other material	BBRC(Biochemical and Biophysical Research Communications), 459, 411-415(2015)
Title of the paper	Thr160 of Axin1 is critical for the formation and function of the β-catenin destruction complex

Title of the research project	Elucidating how the auditory information is integrated by morphological techniques
Recipient (Institution)	Tetsufumi Ito (University of Fukui, Faculty of Medical Sciences, Assistant Professor)
Journal article / other material	The Journal of Comparative Neurology 00:00-00, (2015)
Title of the paper	Convergence of Lemniscal and Local Excitatory Inputs on Large GABAergic Tectothalamic Neurons
Journal article / other material	Brain Research doi.org/10.1016 (2014)
Title of the paper	Determining auditory-evoked activities from multiple cells in layer 1 of the dorsal cortex of the inferior colliculus of mice by in vivo calcium imaging

Title of the research project	Membrane type-1 matrix metalloproteinase in multiple myeloma: a novel modulator of the microenvironment
Recipient (Institution)	Beate Heissig (The University of Tokyo, The Institute of Medical Science, Associate Professor)
Journal article / other material	Leukemia 29,145-156 (2015)
Title of the paper	Inhibition of plasmin attenuates murine acute graft-versus-host disease mortality by suppressing the matrix metalloproteinase-9-dependent inflammatory cytokine storm and effector cell trafficking

Title of the research project	Research on the role of the novel adipocytokine in heart disease
Recipient (Institution)	Noriyuki Ouchi (Nagoya University, Graduate School of Medicine, Professor)
Journal article / other material	The FASEB Journal Vol.29 January 141-151 (2015)
Title of the paper	Adipose-derived protein omentin prevents neointimal formation after arterial injury
Journal article / other material	Circ Heart Fail DOI:10.1161/114.001647(2015)
Title of the paper	Neuron-Derived Neurotrophic Factor Ameliorates Adverse Cardiac Remodeling After Experimental Myocardial Infarction

Title of the research project	The apoptosis-inducing mechanism of biselyngbyaside, a marine macrolide
Recipient (Institution)	Kiyotake Suenaga (Keio University, Faculty of Science and Technology, Associate Professor)
Journal article / other material	Organic Letters, 17, 652-655 (2015)
Title of the paper	Jahanyne, an Apoptosis-Inducing Lipopeptide from the Marine Cyanobacterium Lyngbya sp.
Journal article / other material	Journal of Natural Products78, 901-908 (2015)
Title of the paper	Mebamamides A and B, Cyclic Lipopeptides Isolated from the Green Alga Derbesia marina

Title of the research project	Functional analysis of a novel suppressive factor at fertilization
Recipient (Institution)	Naofumi Miwa (Toho University, School of Medicine, Associate Professor)
Journal article / other material	Molecules 20, 9468-9486 (2015)
Title of the paper	Protein-Carbohydrate Interaction between Sperm and the Egg-Coating Envelope and Its Regulation by Dicalcin, a Xenopus laevis Zona Pellucida Protein-Associated Protein

Title of the research project	Elucidation of the novel signal network that regulates trafficking of secretory lysosomes
Recipient (Institution)	Yoshinori Fukui (Kyushu University, Medical Institute of Bioregulation, Professor)
Journal article / other material	The Journal of Experimental Medici: Vol.211 No.7 1407-14019 (2014)
Title of the paper	DOCK5 functions as a key signaling adaptor that links FcƐRI signals to microtubule dynamics during mast cell degranulation

Title of the research project	The Identification of Exosomal Micro RNA Specific for the Recurrence of Hepatocellular Carcinoma
Recipient (Institution)	Keishi Sugimachi (Kyushu University Beppu Hospital, Associate Professor)
Journal article / other material	British Journal of Cancer: doi: 10.1038/bjc 2014.621 (2014)
Title of the paper	Identification of a bona fide microRNA biomarker in serum exosomes that predicts hepatocellular carcinoma recurrence after liver transplantation

Title of the research project	Development of a novel catalytic asymmetric method for the incorporation of a biologically significant trifluoromethyl group
Recipient (Institution)	Yoshitaka Hamashima (University of Shizuoka, School of Pharmaceutical Sciences, Professor)
Journal article / other material	Chemistry European Journal doi:10.1002/chem.201403447 20, 12061-12065 (2014)
Title of the paper	Dual Catalysis wit Copper and Rhenium for Trifluoromethylation of Propargylic Alcohols: Efficient Synthesis of α-Trifluoromethylated Enones

Title of the research project	Spatiotemporal analysis of oncogenic signaling by Kit tyrosine kinase ～Mechanism of autonomous proliferation in mastocytosis and gastrointestinal stromal tumor (GIST)～
Recipient (Institution)	Yuuki Obata (Tokyo University of Science, Research Institute for Biomedical Sciences, Assistant Professor)
Journal article / other material	Nature Communications Doi: 10.1038/ncomms6715
Title of the paper	Oncogenic Kit signals on endolysosomes and endoplasmic reticulum are essential for neoplastic mast cell proliferation

FY2012 Grant Recipients

Title of the research project	Molecular mechanism of temperature response through secretory signaling
Recipient (Institution)	Atsushi Kuhara (Faculty of Science and Engineering, Konan University)
Journal article / other material	Neurosci Res, 76, 119-24 (2013)
Title of the paper	Molecular mechanism for trimetric G protein-coupled thermosensation and synaptic regulation in the temperature repsonse circuit of Caenorhabditis elegans

Title of the research project	Elucidation of the mechanisms by which impaired clearance of apoptotic cells results in severe inflammation
Recipient (Institution)	Hiroyasu Nakano (Graduate School of Medicine, Juntendo University)
Journal article / other material	Biochem Biophys Res Commun, 436, 212-6 (2013)
Title of the paper	Critical contribution of oxidative stress to TNF α-induced necrosis downstream of RIPK1 activation

Title of the research project	Comprehensive proteomicanalysis of molecules that are targeted for cancer prognosis or therapy
Recipient (Institution)	Kiyotsugu Yoshida (School of Medicine, Jikei University)
Journal article / other material	Proc Natl Acad Sci USA , 111, 717-22 (2014)
Title of the paper	Induction of amphyregulin by p53 promotes apoptosis via control of microRNA biogenesis in response to DNA damage
Journal article / other material	Cancer Lett, 339, 214-25 (2013)
Title of the paper	DYRK2 controls the epithelial-mesenchymal transition in breast cancer by degrading Snail

Title of the research project	Explorative study on lysine demethylase inhibitors by rational drug design
Recipient (Institution)	Takayoshi Suzuki (Department of Chemistry, Kyoto Prefectural University of Medicine)
Journal article / other material	J Med Chem, 56, 7222-31 (2013)
Title of the paper	Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity
Journal article / other material	Angew Chem Int Ed Engl, 52, 8620-4 (2013)
Title of the paper	Lysine-specific demethylase 1-selective inactivators: protein-targeted drug delivery mechanism
Journal article / other material	Comput Struct Biotechnol J, 9, e201402002 (2014)
Title of the paper	Synthesis, LSD1 inhibitory activity, and LSD1 binding model of optically pure lysine-PCPA conjugates

Title of the research project	Synthesis of anticancer anthracycline antibiotics having aza-spiro structure
Recipient (Institution)	Mitsuru Kitamura (Graduate School of Engineering, Kyushu Institute of Technology)
Journal article / other material	Tetrahedron Lett, 55, 1653-6 (2014)
Title of the paper	Synthetic study of kosinostatin aglycone: synthesis of BCDE rings using alkoxycarbonylmethylation of diazonaphtoquinone

Title of the research project	Identification of cytidine deaminase activity for elucidating the molecular mechanism of plant organelle RNA editing
Recipient (Institution)	Mamoru Sugita (Center for Gene Research, Nagoya University)
Journal article / other material	Plant Cell Physiol, 54, 1907-16 (2013)
Title of the paper	Two DYW subclass PPR proteins are involved in RNA editing of ccmFc and atp9 transcripts in the Moss Physcomitrella patens: first completes set of PPR editing factors in plant mitochondria

Title of the research project	RAC1 inhibitor is an anti-tumor metastasis drug
Recipient (Institution)	Satoru Yokoyama (Institute of Natural Medicine, Toyama University)
Journal article / other material	Cancer Sci, 105, 788-94 (2014)
Title of the paper	RAC1 inhibition as a therapeutic target for gefitinib-resistant non-small-cell lung cancer

Title of the research project	Molecular mechanism of Derlin family-mediated novel endoplasmic reticulum quality control system
Recipient (Institution)	Hideki Nishitoh (Department of Medical Sciences, University of Miyazaki)
Journal article / other material	Genes(Basel), 4, 306-33 (2013)
Title of the paper	Signaling pathways from the endoplasmic reticulum and their roles in disease

Title of the research project	Epigenetic regulation by nuclear pore complex in cancer progression.
Recipient (Institution)	Richard Wong (Institute of Science and Engineering, Kanazawa University)
Journal article / other material	Cell Cycle, 10, 1456-67 (2011)
Title of the paper	RNA export factor RAE1 contributes to NUP98-HOXA9-mediated leukemogenesis

Title of the research project	Elucidation of molecular functions of Imp3 in osteosarcoma progression, and development of novel anti-Imp3 targeted therapeutic approach
Recipient (Institution)	Takatsune Shimizu (Faculty of Pharmaceutical Sciences, Hoshi University)
Journal article / other material	Cancer Res, 74, 6531-41 (2014)
Title of the paper	IGF2 preserves osteosarcoma cell survival by creating an autophagic state of dormancy that protects cells against chemotherapeutic stress

Title of the research project	Synthetic Studies on the virulent cell wall lipid of Mycobacterium tuberculosis
Recipient (Institution)	Seijiro Hosokawa (Faculty of Science and Engineering, Waseda University)
Journal article / other material	Org Lett, 16, 4106-9 (2014)
Title of the paper	Stereoselective acylation of the E,E-vinylketene Silyl N,O-acetal and its application to the synthesis of khafrefungin

Title of the research project	Development of an orange-colored bimolecular fluorescence complementation (BiFC) assay
Recipient (Institution)	Yutaka Kodama (Center for Bioscience Research and Education, Utsunomiya University)
Journal article / other material	The 12th Japan Prize in Agrecultural Sciences, Achievement Award for Young Scientists (The Foundation of Agrecultural Sciences of Japan)
Title of the paper	Visualization of protein-protein interactions in living cells

Title of the research project	Regulation of plasma membrane receptor-like kinase functions by endoplasmic reticulum quality control in plant cells
Recipient (Institution)	Shuh-ichi Nishikawa（Faculty of Science, Niigata University）
Journal article / other material	Plant Physiology,182,1979－1990（2020）
Title of the paper	ERdj3B-Mediated Quality Control Maintains Anther Development at High Temperatures

FY2011 Grant Recipients

Title of the research project	Molecular mechanism of self-renewal and proliferation of a hematopoietic cell due to HMGA2 expression
Recipient (Institution)	Kazuhiko Ikeda (Department of Cardiology and Hematology, Fukushima Medical University)
Journal article / other material	Clin Lymphoma Myeloma Leuk, 14, e69-72 (2014)
Title of the paper	Somatic 15q break after long-term stable disease in acute myeloid leukemia
Journal article / other material	Br J Haematol, 168, 388-49 (2015)
Title of the paper	Dysregulation of the MIRLET7/HMGA2 axis with methylation of the CDKN2A promoter in myeloproliferative neoplasms

Title of the research project	The Role of transcription factor Iκβ-ζ in immunity homeostasis
Recipient (Institution)	Takashi Maruyama (Graduate School of Life Sciences, Tohoku University)
Journal article / other material	PLoS One, 9, e110838 (2014)
Title of the paper	The nuclear IκB family protein IκB_NS influences the susceptibility to experimental autoimmune encephalomyelitis in a murine model

FY2007 Grant Recipients

Title of the research project	Analysis of new zebrafish mutants that show the defects in gut epithelium formation.
Recipient (Institution)	Yutaka Kikuchi (Graduate School of Science, Hiroshima University)
Journal article / other material	PLoS One, 7, e33675 (2012)
Title of the paper	DEAD-box protein Ddx46 is required for the development of the digestive organs and brain in zebrafish